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Canidryl (5 - 10 kg)
Active substance
ATC code
Species
Dogs.
Indications
Reduction of inflammation and pain caused by musculo-skeletal disorders and degenerative joint disease. As a follow up to parenteral analgesia in the management of post-operative pain following soft tissue surgery.
Dose to be administered and administration route
Oral use.
4 mg carprofen per kg body weight per day.
An initial dose of 4 mg carprofen per kg bodyweight per day given as a single daily dose or in two equally divided doses may, subject to clinical response, be reduced after 7 days to 2 mg carprofen/kg bodyweight/day given as a single dose.
Duration of treatment will be dependent upon the response seen. Long term treatment should be under regular veterinary supervision.
To extend analgesic and anti-inflammatory cover post-operatively, parenteral preoperative treatment may be followed with carprofen tablets at 4mg/kg/day for 2 days.
Do not exceed the stated dose.
Adverse reactions
Dogs:
|
Rare (1 to 10 animals / 10 000 animals treated): |
Renal disorder, Hepatic disorder1 |
|
Very rare (<1 animal / 10 000 animals treated, including isolated reports): |
Vomiting2, soft stool2, diarrhea2, Blood in faeces2,3, appetite loss2, lethargy2 |
1Idiosyncratic reaction.
2Transient. Generally occur within the first treatment week and disappear following termination of the treatment. In very rare cases may be serious or fatal.
3Occult
If adverse events occur, use of the veterinary medicinal product should be stopped and the advice of a veterinarian should be sought.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Dispensing
POM-V
TRUSTED SOURCE
SUMMARY OF PRODUCT CHARACTERISTICS
1. NAME OF THE VETERINARY MEDICINAL PRODUCT
Canidryl 20 mg Tablets for Dogs
2. QUALITATIVE AND QUANTITATIVE COMPOSITION
Each grilled meat flavoured tablet contains:
Active substances:
Carprofen 20.0 mg
Excipients:
|
Qualitative composition of excipients and other constituents |
|
Lactose monohydrate |
|
Microcrystalline cellulose |
|
Silica colloidal anhydrous |
|
Grilled Meat flavour 2007.01 |
|
Magnesium stearate |
A plain round flat bevelled edge white tablet with a breakline on one side. The tablets can be divided into equal halves.
3. CLINICAL INFORMATION
3.1 Target species
Dogs.
3.2 Indications for use for each target species
Reduction of inflammation and pain caused by musculo-skeletal disorders and degenerative joint disease. As a follow up to parenteral analgesia in the management of post-operative pain following soft tissue surgery.
3.3 Contraindications
Do not use in cats.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Do not use in dogs suffering from cardiac, hepatic or renal disease, where there is a possibility of gastro-intestinal ulceration or bleeding, or where there is evidence of a blood dyscrasia.
3.4 Special warnings
None
3.5 Special precautions for use
Special precautions for safe use in the target species:
Use in dogs less than 6 weeks of age, or in aged dogs, may involve additional risk. If such a use cannot be avoided, dogs may require careful clinical management. Avoid use in any dehydrated, hypovolaemic or hypotensive dog, as there is a potential risk of increased renal toxicity.
Concurrent administration of potential nephrotoxic drugs should be avoided.
NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
In case of accidental ingestion of the tablets, seek medical advice immediately and show the package leaflet or the label to the physician.
Wash hands after handling the veterinary medicinal product.
Special precautions for the protection of the environment:
Not applicable.
3.6 Adverse events Dogs:
|
Rare (1 to 10 animals / 10 000 animals treated): |
Renal disorder, Hepatic disorder[1] |
|
Very rare (<1 animal / 10 000 animals treated, including isolated reports): |
Vomiting[2], soft stool2, diarrhea2, Blood in faeces2,3, appetite loss2, lethargy2 |
to either the marketing authorisation holder or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
3.7 Use during pregnancy, lactation or lay
Pregnancy and lactation:
The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Laboratory studies (rats and rabbits) have shown evidence of foetotoxic effects of carprofen at doses close to the therapeutic dose. Do not use in pregnant or lactating bitches.
3.8 Interaction with other medicinal products and other forms of interaction
Carprofen must not be administered with glucocorticoids.
See section 3.5.
Do not administer other NSAIDs concurrently or within 24 hours of each other. Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs, which can lead to toxic effects
3.9 Administration routes and dosage
Oral use.
4 mg carprofen per kg body weight per day.
An initial dose of 4 mg carprofen per kg bodyweight per day given as a single daily dose or in two equally divided doses may, subject to clinical response, be reduced after 7 days to 2 mg carprofen/kg bodyweight/day given as a single dose.
Duration of treatment will be dependent upon the response seen. Long term treatment should be under regular veterinary supervision.
To extend analgesic and anti-inflammatory cover post-operatively, parenteral preoperative treatment may be followed with carprofen tablets at 4mg/kg/day for 2 days.
Do not exceed the stated dose.
3.10 Symptoms of overdose (and where applicable, emergency procedures and antidotes)
No signs of toxicity appeared when dogs were treated with carprofen at levels up to
6 mg/kg twice daily for 7 days (3 times the recommended dose rate of 4mg/kg) and 6mg/kg once daily for a further 7 days. (1.5 times the recommended dose rate of 4 mg/kg). There is no specific antidote for carprofen overdosage but general supportive therapy, as applied to clinical overdosage with NSAIDs should be applied.
3.11 Special restrictions for use and special conditions for use, including restrictions on the use of antimicrobial and antiparasitic veterinary medicinal products in order to limit the risk of development of resistance
Not applicable.
3.12 Withdrawal periods
Not applicable.
4. PHARMACOLOGICAL INFORMATION
4.1 ATCvet code:
QM01AE91.
4.2 Pharmacodynamics
Carprofen is a member of the 2-arylpropionic acid group of non-steroidal antiinflammatory drugs (NSAIDs), and possesses anti-inflammatory, analgesic and antipyretic activity. Carprofen is a chiral drug with the S(+) enantiomer being more active than the R(-) enantiomer. Carprofen, like most other NSAIDs is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its antiinflammatory and analgesic potency. The precise mode of action of carprofen is not clear.
4.3 Pharmacokinetics
After oral administration, carprofen is well absorbed in the dogs. Following the administration of the veterinary medicinal product in dogs, a mean Cmax (maximum concentration in serum) of 15.8 μg/ml and 12.2 μg/ml was achieved at approximately 2 hours and 1.7 hours for carprofen R(-) and carprofen S(+), respectively. For both enantiomers, the mean half-life was approximately 6 hours. The analgesic effect from each dose persists for at least 12 hours.
Carprofen has a small volume of distribution and a low systemic clearance. It is highly bound to plasma protein.
Carprofen is metabolised in the liver by conjugation and oxidation. The excretion of the glycuronide conjugate is mainly faecal after biliary excretion.
5. PHARMACEUTICAL PARTICULARS
5.1 Major incompatibilities
Not applicable.
5.2 Shelf life
Shelf-life of the veterinary medicinal product packaged in blister packs: 4 years.
Shelf-life of the veterinary medicinal product packaged in HDPE containers: 3 years. Any divided and unused tablets should be discarded immediately.
5.3 Special precautions for storage
Store in a dry place.
Store in the original package. Protect from light.
5.4 Nature and composition of immediate packaging
i) White High Density Polyethylene (HDPE) Twist-off plastic containers with child proof tamper evident Polypropylene white twist-off closures. The containers are Packed in a cardboard box. ii) Blister packs made up of a PVC/PVdC (250 µm/40 g/m2) with a 20mu Hard Temper Aluminium Foil. The Blister packs are Packed in a cardboard box.
Pack sizes: Blisters
Box containing 6 tablets (1 blister pack with 6 tablets).
Box containing 10 tablets (1 blister pack with 10 tablets).
Box containing 14 tablets (1 blister pack with 14 tablets).
Box containing 20 tablets (2 blister pack with 10 tablets).
Box containing 28 tablets (2 blister pack with 14 tablets).
Box containing 30 tablets (3 blister pack with 10 tablets).
Box containing 42 tablets (3 blister pack with 14 tablets).
Box containing 50 tablets (5 blister pack with 10 tablets).
Box containing 56 tablets (4 blister pack with 14 tablets).
Box containing 60 tablets (6 blister pack with 10 tablets).
Box containing 70 tablets (5 blister pack with 14 tablets each, or 7 blister pack with 10 tablets each).
Box containing 84 tablets (6 blister pack with 14 tablets).
Box containing 98 tablets (7 blister pack with 14 tablets).
Box containing 100 tablets (10 blister pack with 10 tablets).
Box containing 140 tablets (10 blister pack with 14 tablets each, or 14 blister pack with 10 tablets each).
Box containing 180 tablets (18 blister pack with 10 tablets)
Box containing 200 tablets (20 blister pack with 10 tablets)
Box containing 250 tablets (25 blister pack with 10 tablets)
Box containing 280 tablets (28 blister pack with 10 tablets each, or 20 blister pack with 14 tablets each).
Box containing 300 tablets (30 blister pack with 10 tablets)
Box containing 500 tablets (50 blister pack with 10 tablets) Box containing 1000 tablets (100 blister pack with 10 tablets)
Pack sizes for containers:
The container pack sizes and volumes are as follows:
20 mg:
|
Pack size |
Container volume |
|
6, 10, 14, 20, 28, 30, 42, 50, 60, 70, 84 |
15 ml |
|
98, 100, 140 |
30 ml |
|
180, 200 |
50 ml |
|
250, 280, 300 |
75 ml |
|
500 |
100 ml |
|
1000 |
250 ml |
Not all pack sizes may be marketed.
5.5 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products
Medicines should not be disposed of via wastewater.
Use take-back schemes for the disposal of any unused veterinary medicinal product or waste materials derived thereof in accordance with local requirements and with any national collection systems applicable to the veterinary medicinal product concerned.
6. NAME OF THE MARKETING AUTHORISATION HOLDER
Chanelle Pharmaceuticals Manufacturing Ltd
7. MARKETING AUTHORISATION NUMBER
Vm 08749/4009
8. DATE OF FIRST AUTHORISATION
12 December 2006
9. DATE OF THE LAST REVISION OF THE SUMMARY OF THE PRODUCT CHARACTERISTICS
October 2026
10. CLASSIFICATION OF VETERINARY MEDICINAL PRODUCT
Veterinary medicinal product subject to prescription.
Find more product information by searching for the ‘Product Information Database’ on www.gov.uk.
Approved 07 October 2026
[1] Idiosyncratic reaction.
[2] Transient. Generally occur within the first treatment week and disappear following termination of the treatment. In very rare cases may be serious or fatal. 3Occult
If adverse events occur, use of the veterinary medicinal product should be stopped and the advice of a veterinarian should be sought.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
| Art. Nr. | 08749/4009 |
|---|
