M+PAC
Active substance
ATC code
Species
Pig (fattening pigs, from 7 days of age).
Indications
For the active immunization of pigs in order to reduce frequency and severity of lung lesions caused by Mycoplasma hyopneumoniae.
For vaccination with 2 doses of 1 ml given 2-4 weeks apart, protection has been demonstrated 35 days post initial dose and the duration of immunity is at least 6 months. In field studies, only seroconversion has been demonstrated in pigs receiving two 1 ml doses.
For vaccination with 1 dose of 2 ml, protection has been shown 24 days after vaccination and duration of immunity is at least 6 months after vaccination.
Dose to be administered and administration route
Pigs from 7 days of age: 1 dose of 1 ml. This 1 ml dose should be repeated after 14 – 28 days.
Pigs from 21 days of age: 1 single dose of 2 ml or 2 doses of 1 ml administered at an interval of 14-28 days.
Vaccinate pigs by the intramuscular route, preferably on alternate sides of the neck.
The vial should be well shaken before withdrawing a dose. There is no need to warm the vaccine before use. Syringes and needles must be sterile before use. The injection should be performed in a clean and dry skin area, taking appropriate precaution to avoid contamination.
Follow usual aseptic procedures.
Adverse reactions
A small proportion of pigs may experience polypnea and dizziness within 5-10 minutes of first vaccination. This resolves within 4 hours without treatment or further adverse effect on the animal. An increase in respiration rate may also occur in a small proportion of piglets within a few hours of injection with either a 1 or 2 ml dose. Hyperthermia may occur in a small proportion of piglets given 1 ml (<39.8°C) and a higher proportion given 2 ml (mean 40.2°C), returning to normal within 24-48 hours. Adverse reactions are uncommon after the second vaccination. Local reactions at the injection site are common but are restricted to a slight swelling (<2 cm diameter) which disappears within 24-48 hours of injection. In rare cases a granuloma may occur in the muscle at the injection site which may last over 21 days but resolves over time. Correct aseptic technique will reduce this possibility further. [These observations were made during small scale laboratory studies and field trials].
In rare cases, emesis, dyspnoea, ataxia, muscle tremor, convulsion, diarrhoea, lethargy or anorexia may be observed following vaccination.
In the event of hypersensitivity reactions (shock), appropriate treatment such as adrenaline should be administered without delay.
