Bovilis IBR Marker live
Active substance
ATC code
Species
Cattle.
Indications
Active immunisation of cattle to reduce the intensity and duration of the clinical respiratory signs induced by an infection with BHV-1 and to reduce nasal excretion of field virus.
Onset of immunity:
An increase in immunity was demonstrated 4 days after intranasal vaccination and 14 days after intramuscular vaccination of 3 month old seronegative animals.
Duration of immunity:
After intranasal administration to 2 week old calves immunity lasts at least until the age of 3-4 months. In the presence of maternally derived antibodies, the protection of the vaccine may not be complete until a second vaccination. This second vaccination should be administered at 3-4 months of age and will result in protective immunity that lasts for at least 6 months.
Single intranasal or intramuscular vaccination of 3 months old animals provides protective immunity (reduction of clinical signs and reduction of viral excretion), which was demonstrated via challenge 3 weeks after vaccination. Reduction of viral excretion is maintained for at least 6 months after single vaccination.
Revaccination to ensure protection after the initial 6 month protection period has elapsed will result in protective immunity that lasts for 12 months.
Specific information:
No information is available on the efficacy of the vaccine to prevent a latent wild virus infection or to prevent wild virus re-excretion in the latent carrier.
Dose to be administered and administration route
Reconstitute the lyophilisate with the solvent
| Number of doses per vial | Volume (ml) of solvent needed | |
| 5 | 10 | |
| 10 | 20 | |
| 25 | 50 | |
| 50 | 100 | |
| 100 | 200 |
Dosage: a single dose of 2 ml reconstituted vaccine per animal.
Method of administration:
- from the age of 3 months onwards: intranasal use or intramuscular use.
- at an age between 2 weeks and 3 months: intranasal use.
For intranasal use (1 ml in each nostril), the use of a nozzle is recommended.
Primary vaccination:
- Basic vaccination:
Vaccinate each animal from 3 months of age onwards with one single dose.
- Early protection schedule:
When the first vaccination is given between the age of 2 weeks and 3 months, a second vaccination should be given at an age of 3-4 months.
First revaccination:
The first revaccination should be given 6 months after primary vaccination. Bovilis IBR marker inac can alternatively be used for this revaccination.
Subsequent revaccinations:
All following revaccinations should be given at an interval no greater than 12 months. Bovilis IBR marker inac can alternatively be used for these revaccinations.
The product literature of Bovilis IBR marker inac should be consulted before using it for revaccination.
For revaccination, the lyophilisate may be reconstituted shortly before use with Bovilis BVD for use in cattle from 15 months of age (i.e. those that have previously been vaccinated separately with Bovilis IBR marker live and Bovilis BVD). The following instructions should be used:
|
Bovilis IBR marker live |
Bovilis BVD |
|
|
5 doses |
+ |
10 ml |
|
10 doses |
+ |
20 ml |
|
25 doses |
+ |
50 ml |
|
50 doses |
+ |
100 ml |
A single dose (2 ml) of Bovilis IBR marker live mixed with Bovilis BVD is given intramuscularly.
Shelf life after mixing with Bovilis BVD: 3 hours
Use sterile vaccination equipment free from disinfectants. To prevent the spread of any infective agents the intranasal equipment should be changed at each animal.
Visual appearance after reconstitution
- In solvent: colourless to slightly opaque solution.
- In Bovilis BVD: as specified in the product information for Bovilis BVD alone.
Adverse reactions
A slight transient rise in temperature (1°C) can commonly occur up to 5 days post vaccination.
An increase of nasal discharge can be commonly observed after intranasal vaccination.
In very rare cases hypersensitivity reactions can occur.
The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
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|---|---|
| Art. Nr. | 01708/5095 |
| EAN | 8713184136169 |
