Tetanus Antitoxin Behring
Active substance
ATC code
Species
Horse, sheep and dog.
Indications
Tetanus Antitoxin Behring is intended for prophylactic use in horses, sheep and dogs to reduce the risk of tetanus infection, as a result of accidental injury or as a preoperative precaution.
After subcutaneous and intramuscular injection of Tetanus Antitoxin Behring, maximum serological titres can be expected approximately 2 days after administration. The titres slowly decrease with time, but the protective effect lasts for between 2 and 3 weeks.
Tetanus Antitoxin Behring is intended for therapeutic use in horses and dogs to enhance recovery rates in animals showing clinical signs of tetanus, when combined with other treatments
After intravenous or intramuscular injection to horses, serological titres associated with protection can be reached within one to four hours.
After subarachnoidal injection effective titres in the central nervous system are reached straight after application. The duration of effective antibody titres has not been investigated in the central nervous system. The intravenous and subarachnoidal application routes are recommended for therapeutic use of Tetanus Antitoxin Behring in horses only.
Dose to be administered and administration route
I. Dosage and method of administration in horses
I.a Prophylaxis:
Method of administration:
Subcutaneous or intramuscular application.
Dosage for pre-operation treatment or after injury:
|
Horse |
7,500 - 10,000 IU = 7.5 - 10 ml |
|
Foal with body weight up to 100 kg |
3,000 IU = 3.0 ml |
If the operation wound or the injury has not improved after 10-14 days the serum application has to be repeated (see 4.4).
Simultaneous with vaccination
Application: subcutaneously or intramuscularly.
Tetanus Antitoxin Behring and vaccines* against tetanus are to be applied at different parts of the body. Dosage see 'prophylaxis'.
I.b Therapeutic:
Method of administration:
Application preferably intravenously, otherwise subcutaneously or intramuscularly. To supply the central nervous system with antitoxin the administration of Tetanus Antitoxin Behring into the subarachnoid space is recommended (see also point 4.6).
___________________________
* Equilis Prequenza Te and Equilis Te. For proper use please refer to the relevant product leaflets.
Dosage:
|
Horse |
20,000 - 50,000 IU = 20 – 50 ml |
|
Foal with body weight up to 100 kg |
30,000 IU = 30 ml |
The given doses should be applied in an as early as possible stage of the disease. A repeated administration on the two following days can be useful.
II. Dosage and method of administration in sheep
Method of administration:
Subcutaneous application.
The dosage for pre-operation treatment or after injury should contain:
|
Sheep (subcutaneous) |
3,000 IU = 3.0 ml |
|
Lamb (subcutaneous) |
1,500 IU = 1.5 ml |
III. Dosage and method of administration in dogs
Method of administration:
Subcutaneous or intramuscular application.
a. The dosage for pre-operation treatment or after injury should contain:
|
Dog (intramuscular) depending on the body weight (80 IU/kg) |
Min 500 – max 2,500 IU = 0.5 – 2.5 ml |
b. The therapeutical dosage should contain:
|
Dog (intramusculat) depending on the body weight (1000 IU/kg) |
Min 10,000 – max 20,000 IU = 10 – 20 ml |
Adverse reactions
A transient local swelling may occur after vaccination. A transient rise in body temperature may occasionally occur on the day of application and the day after. In very rare cases, especially after repeated administration, hypersensitivity reactions may occur. Especially heterologous animals are susceptible (see 4.4).
It has been concluded from studies that the product is unlikely to exacerbate the disease when it is administered to horses affected with clinical tetanus, with doses of 20,000 to 50,000 IU, administered by the intramuscular, subcutaneous or intravenous routes, if necessary repeated at intervals over the space of a few days, or by injection into the subarachnoid space.
TRUSTED SOURCE
