Bovilis Bovivac S
Active substance
ATC code
Species
Cattle
Indications
For the active immunisation of cattle in order to induce serological and colostral antibody production against Salmonella dublin and Salmonella typhimurium and in the face of an outbreak to reduce Salmonella typhimurium infections when used under field conditions as part of an overall herd management programme. Bovilis Bovivac S may also contribute to reducing S. typhimurium contamination of the environment.
Specific experimental data to quantify the duration of immunity or the degree of protection from colostral antibodies has not been generated.
Significant levels of immunity cannot be expected until two weeks after the second dose of the primary vaccination course.
Dose to be administered and administration route
Vaccination dosage:
Calves up to 6 months of age – 2 ml Adult cattle – 5 ml.
Route of administration
Subcutaneous injection preferably in the loose skin on the side of the neck, observing aseptic precautions. The use of automatic vaccination equipment is recommended. The vaccine may be administered using a sterile needle and syringe, providing a fresh sterile needle is used each time the rubber cap is punctured, to avoid contamination of the remaining contents.
Primary vaccination course
Where diagnosis of salmonellosis caused by S. dublin and/or S. typhimurium has been confirmed, all at risk adult cattle, including lactating cows, dry cows, heifers, barren cows and in-contact bulls (but excluding any with overt clinical signs of salmonellosis), should receive two 5 ml injections separated by an interval of 21 days.
For pregnant cows, this primary vaccination course can be given irrespective of the reproductive status. Any pregnant cows that have not calved within 8 weeks of the second dose of vaccine should receive a further 5 ml dose of Bovilis Bovivac S 3-4 weeks precalving.
Healthy calves from approximately 3 weeks of age may also be given a primary vaccination course. Calves should be given two 2 ml injections separated by an interval of 14 to 21 days.
Re-vaccination scheme
All cattle vaccinated with the primary vaccination course of Bovilis Bovivac S should receive a 5 ml injection at least two weeks prior to each period of risk or at intervals of not more than 12 months thereafter.
As part of an overall herd management programme, for pregnant cattle, it is advised that for each subsequent pregnancy, in order to maintain a sufficient level of active immunisation to reduce S. dublin and S. typhimurium infections under field conditions, a single injection of 5 ml should be administered approximately 3-4 weeks before calving. The efficacy of Bovilis Bovivac S has been established in the field using the recommended programme of use. No specific experimental data are available in support of the effectiveness of a single dose re-vaccination.
The use of automatic vaccination equipment is recommended. Use a vaccinator with vented draw-off spike or similar device only.
Adverse reactions
Swellings at the injection site may occur. Typically, these swellings may be warm when compared to the surrounding area for up to 5 days after vaccination, reach a maximum size within 1-6 days after vaccination and completely disappear or reduce to clinically insignificant reactions within 2-3 weeks after vaccination. In addition, swellings may be slightly painful on palpation for 1-2 days after vaccination, although this will not require veterinary intervention.
Occasional hypersensitivity reactions may occur.
