Doxatib
Active substance
ATC code
Species
Pig and chicken (broiler, pullet, for reproduction).
Indications
Pigs: For the treatment of the clinical signs associated with porcine respiratory disease caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, and Mycoplasma hyopneumoniae susceptible to doxycycline.
Chickens: Where clinical disease is present in the flock, to reduce mortality, morbidity, and clinical signs and to reduce lesions due to Pasteurellosis caused by Pasteurella multocida or to reduce morbidity and lesions in respiratory infections caused by Ornithobacterium rhinotracheale (ORT).
Dose to be administered and administration route
In drinking water use .
Pigs: the recommended dose is:
12.5 mg doxycycline hyclate (25 mg veterinary medicinal product) per kg body weight per day for 4 consecutive days.
If no improvement in clinical signs is seen within this time, the diagnosis should be reviewed and treatment changed. In case of severe infections the medication period may be prolonged for a maximum of 8 consecutive days as determined by the attending veterinary surgeon.
Chickens: the recommended dose is:
10 mg doxycycline hyclate (20 mg veterinary medicinal product) per kg body weight per day for 3-4 consecutive days in case of infections caused by P. multocida and 20 mg doxycycline hyclate (40 mg veterinary medicinal product) per kg body weight per day for 3-4 consecutive days in case of infections caused by O. rhinotracheale.
Based on the recommended dose to be used and the number and weight of the animals to be treated, the exact daily concentration of the veterinary medicinal product should be calculated according to the following formula:
To ensure a correct dosage, body weight should be determined as accurately as possible to avoid underdosing.
The intake of medicated water depends on the clinical condition of the animals. In order to obtain the correct dosage, the concentration of doxycycline may need to be adjusted accordingly.
The use of suitably calibrated weighing equipment is recommended if part packs are used. The daily amount is to be added to the drinking water such that all medication will be consumed in 24 hours. Medicated water should be replaced every 24 hours.
It is recommended to prepare a concentrated pre-solution - approximately 100 grams product per litre drinking water - and to dilute this further to therapeutic concentrations if required. Alternatively, the concentrated solution can be used in a proportional water medicator.
Solubility of the veterinary medicinal product is pH dependent and it may precipitate if it is mixed in hard alkaline drinking water. Use at minimum concentrations of 200 mg powder per litre drinking water in areas with hard alkaline drinking water (hardness above 10.2 °d and pH more than 8.1).
Do not store the medicated water in metallic containers.
It should be ensured that all animals intended for treatment should have free access to the drinking facilities.
During the treatment period animals should not have access to other water sources than the medicated water.
Water uptake should be monitored at frequent intervals during medication.
After the end of the medication period, the water supply system should be cleaned appropriately to avoid intake of sub-therapeutic amounts of the active substance.
Adverse reactions
Pig and chicken:
|
Very rare (<1 animal / 10,000 animals treated, including isolated reports): |
Allergic condition* Photosensitivity* |
*If suspected adverse reactions occur, treatment should be discontinued.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or the national competent authority via the national reporting system. See also the section “Contact details” of the package leaflet for contact details.
References
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