Prinovox (4 - 10 kg)
ATC code
Species
Dogs (> 4–10 kg)
Indications
For dogs suffering from, or at risk from, mixed parasitic infections:
• the treatment and prevention of flea infestation (Ctenocephalides felis),
• the treatment of biting lice (Trichodectes canis),
• the treatment of ear mite infestation (Otodectes cynotis), sarcoptic mange (caused by Sarcoptes scabiei var. canis), demodicosis (caused by Demodex canis),
• the prevention of heartworm disease (L3 and L4 larvae of Dirofilaria immitis),
• the treatment of circulating microfilariae (Dirofilaria immitis),
• the treatment of cutaneous dirofilariosis (adult stages of Dirofilaria repens),
• the prevention of cutaneous dirofilariosis (L3 larvae of Dirofilaria repens),
• the reduction of circulating microfilariae (Dirofilaria repens),
• the prevention of angiostrongylosis (L4 larvae and immature adults of Angiostrongylus vasorum),
• the treatment of Angiostrongylus vasorum and Crenosoma vulpis,
• the prevention of spirocercosis (Spirocerca lupi),
• the treatment of Eucoleus (syn. Capillaria) boehmi (adults),
• the treatment of the eye worm Thelazia callipaeda (adults),
• the treatment of infections with gastrointestinal nematodes (L4 larvae, immature adults and adults of Toxocara canis, Ancylostoma caninum and Uncinaria stenocephala, adults of Toxascaris leonina and Trichuris vulpis).
The product can be used as part of a treatment strategy for flea allergy dermatitis (FAD).
Dose to be administered and administration route
Dosage schedule:
The recommended minimum doses are 10 mg/kg bodyweight imidacloprid and 2.5 mg/kg bodyweight moxidectin, equivalent to 0.1 ml of this product per kg bodyweight.
The treatment schedule should be based on individual veterinary diagnosis and on the local epidemiological situation.
|
Weight of dog [kg] |
Pipette size to be used |
Volume [ml] |
Imidacloprid [mg/kg bw] |
Moxidectin [mg/kg bw] |
|
> 4–10 kg |
Prinovox for medium dogs |
1.0 |
10–25 |
2.5–6.25 |
|
Dogs weighing less than 4 kg / over 10 kg bodyweight: use the appropriate Prinovox spot-on solution for dogs |
||||
Flea treatment and prevention (Ctenocephalides felis)
One treatment prevents future flea infestation for 4 weeks. Existing pupae in the environment may emerge for 6 weeks or longer after treatment is initiated, depending upon climatic conditions. Therefore, it may be necessary to combine the treatment with the product with environmental treatments aimed at breaking the flea life cycle in the surroundings. This can result in a more rapid reduction in the household flea population. The product should be administered at monthly intervals when used as part of a treatment strategy for flea allergy dermatitis.
Treatment of biting lice (Trichodectes canis)
A single dose should be administered. A further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment.
Treatment of ear mite infestation (Otodectes cynotis)
A single dose of the product should be administered. Loose debris should be gently removed from the external ear canal at each treatment. A further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment. Do not apply directly to the ear canal.
Treatment of sarcoptic mange (caused by Sarcoptes scabiei var. canis)
A single dose should be administered twice 4 weeks apart.
Treatment of demodicosis (caused by Demodex canis)
The administration of a single dose every 4 weeks for 2 to 4 months is efficacious against Demodex canis and leads to a marked improvement of clinical signs particularly in mild to moderate cases. Especially severe cases may require more prolonged and more frequent treatment. To achieve the best possible response in these severe cases, at the discretion of the veterinarian, the product can be applied once a week and for a prolonged time. In all cases it is essential that the treatment should be continued until skin scrapings are negative on at least 2 consecutive monthly occasions. Treatment should be stopped in dogs that show no improvement or do not respond in mite count after 2 months treatment. Alternative treatment should be administered. Seek the advice of your veterinarian.
As demodicosis is a multi-factorial disease, where possible, it is advisable to also treat any underlying disease appropriately.
Prevention of heartworm disease (D. immitis)
Dogs in areas endemic for heartworm, or those which have travelled to endemic areas, may be infected with adult heartworms. Therefore prior to treatment with this product, the advice provided in section 4.5 should be considered.
For prevention of heartworm disease, the product must be applied at regular monthly intervals during the time of the year when mosquitoes (the intermediate hosts which carry and transmit D. immitis larvae) are present. The product may be administered throughout the year. The first dose may be given after first possible exposure to mosquitoes, but not more than one month after this exposure. Treatment should continue at regular monthly intervals until 1 month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended that the same day or date be used each month. When replacing another heartworm preventative product in a heartworm prevention programme, the first treatment with this product must be given within 1 month of the last dose of the former medication.
In non-endemic areas there should be no risk of dogs having heartworm. Therefore they can be treated without special precautions.
Prevention of cutaneous dirofilariosis (skinworm) (D. repens)
For prevention of cutaneous dirofilariosis, the product must be applied at regular monthly intervals during the time of the year when mosquitoes (the intermediate hosts which carry and transmit D. repens larvae) are present. The product may be administered throughout the year or at least 1 month before the first expected exposure to mosquitoes. Treatment should continue at regular monthly intervals until 1 month after the last exposure to mosquitoes. To establish a treatment routine, it is recommended that the same day or date be used each month.
Treatment of microfilariae (D. immitis)
The product should be administered monthly for two consecutive months.
Treatment of cutaneous dirofilariosis (adult stages of Dirofilaria repens)
The product should be administered monthly for six consecutive months.
Reduction of microfilariae (D. repens)
The product should be administered monthly for four consecutive months.
Treatment and prevention of Angiostrongylus vasorum
A single dose should be administered. A further veterinary examination 30 days after treatment is recommended as some animals may require a second treatment. In endemic areas regular monthly applications will prevent angiostrongylosis and patent infection with Angiostrongylus vasorum.
Treatment of Crenosoma vulpis
A single dose should be administered.
Prevention of Spirocerca lupi
The product should be administered monthly.
Treatment of Eucoleus (syn. Capillaria) boehmi (adults)
The product should be administered monthly for two consecutive months. It is advisable to prevent auto-coprophagia between the two treatments in order to prevent possible reinfection.
Treatment of the eye worm Thelazia callipaeda (adults)
A single dose of the product should be administered.
Roundworm, hookworm and whipworm treatment
In areas endemic for heartworm, monthly treatment may significantly reduce the risk of re-infection caused by the respective round-, hook- and whipworms. In areas nonendemic for heartworm, the product can be used as part of a seasonal prevention programme against fleas and gastrointestinal nematodes.
Studies have shown that monthly treatment of dogs will prevent infections caused by Uncinaria stenocephala.
Method of administration
For external use only.
Remove one pipette from the package. Then hold the pipette in an upright position, and twist and pull off the cap. Reverse the cap and use it to twist and remove the seal from the pipette, as shown.
With the dog in a standing position, part the coat between the shoulder blades until the skin is visible. Wherever possible apply to undamaged skin. Place the tip of the pipette on the skin and squeeze the pipette firmly several times to empty its contents directly onto the skin.
Adverse reactions
Vomiting can occur on rare occasions. Use of the product may result in transient pruritus in dogs. The product may, in rare cases, cause local hypersensitivity reactions. Transient local skin sensitivity reactions including increased itching, hair loss, greasy fur and redness at application site have been reported in very rare cases. These signs disappear without further treatment. In very rare cases, diarrhoea may occur after application of the product. Neurological signs such as ataxia and muscle tremor (most of which are transient) may be observed in very rare cases (see section 4.10).
The product tastes bitter. Salivation may occasionally occur if the animal licks the application site immediately after treatment. This is not a sign of intoxication and disappears within some minutes without treatment. Correct application will minimise licking of the application sites.
The product may in very rare cases cause at the application site a sensation resulting in transient behavioural changes such as lethargy, agitation, and inappetence.
A field study has shown that in heartworm positive dogs with microfilaraemia there is a risk of severe respiratory signs (coughing, tachypnea and dyspnea) that may require prompt veterinary treatment. In the study these reactions were common (seen in 2 of 106 treated dogs). Gastrointestinal signs (vomiting, diarrhoea, inappetence) and lethargy are also common adverse reactions following treatment in such dogs.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
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Prinovox (4 - 10 kg)
Prinovox (4 - 10 kg)
