Ciclosporin

Ciclosporin is an immunosuppressive substance used primarily to manage conditions caused by overactive immune responses. Ciclosporin is used to treat conditions such as allergic dermatitis, autoimmune diseases, and certain types of chronic inflammatory disorders in pets. Read more

Ciclosporin is an immunosuppressive substance used primarily to manage conditions caused by overactive immune responses. Ciclosporin is used to treat conditions such as allergic dermatitis, autoimmune diseases, and certain types of chronic inflammatory disorders in pets.

Essential insights

• Inhibition of T-Cell activation: Ciclosporin specifically targets and inhibits the activity of T-lymphocytes (T-cells), a type of white blood cell involved in the immune response. It binds to a protein called cyclophilin inside T-cells, forming a complex that inhibits calcineurin, an enzyme essential for T-cell activation.
• Suppression of cytokine production: By inhibiting calcineurin, ciclosporin prevents the activation of nuclear factor of activated T-cells (NFAT), which is crucial for the transcription of various cytokines, such as interleukin-2 (IL-2). IL-2 and other cytokines are important for the proliferation and activation of T-cells.
• Reduction of immune response: As a result of reduced T-cell activation and cytokine production, ciclosporin suppresses the overall immune response. This is beneficial for treating autoimmune diseases and controlling inflammatory conditions where the immune system is attacking the body’s own tissues.