Nasym
ATC code
Species
Cattle.
Indications
Active immunisation of cattle to reduce virus shedding and respiratory clinical signs caused by bovine respiratory syncytial virus infection.
Onset of immunity: 21 days after administration of one dose by the nasal route.
21 days after the second dose of the two-dose intramuscular vaccination schedule.
Duration of immunity: 2 months after nasal vaccination.
6 months after intramuscular vaccination.
Dose to be administered and administration route
Nasal use or intramuscular use.
Reconstitute the vaccine with the corresponding volume of solvent:
Number of doses in vial of lyophilisate | Volume of solvent to be used |
1 dose | 2 ml |
5 doses | 10 ml |
25 doses | 50 ml |
1. Peel the top off the aluminium cap on the vial containing the solvent and withdraw 10 ml (2 ml for the 1-dose vial).
2. Inject the solvent into the vial containing the lyophilisate (freeze-dried powder).
3. Shake until the freeze-dried powder is in suspension. The 1- and 5-dose vials are now ready to use.
4. For the 25-dose vial, once the freeze-dried powder is in suspension with the 10 ml of solvent, withdraw all the suspension obtained from the vaccine vial and inject it into the vial containing the remaining solvent.
5. Shake well before use. The reconstituted vaccine is a slightly yellowish homogeneous suspension.
Avoid contamination during reconstitution and use. Use only sterile needles and syringes for administration.
For nasal use, spray the required volume of the vaccine into the animal’s nostrils (1 ml in each nostril) using an intranasal applicator (droplet size: 25–220 µm). It is recommended to use a new applicator for each animal.
The following doses and administration methods should be used:
Cattle from 9 days of age:
Primary vaccination (nasal use): Spray 1 ml into each nostril (so the total volume administered is 2 ml).
Revaccination: One intramuscular injection of 2 ml should be given 2 months after the primary vaccination, and then every 6 months after the last revaccination.
Cattle from 10 weeks of age:
Primary vaccination (intramuscular injection): One intramuscular injection of 2 ml should be given, followed by a second intramuscular injection of 2 ml given 4 weeks later.
Revaccination: One intramuscular injection of 2 ml should be given 6 months after completion of the primary vaccination scheme and then every 6 months after the last revaccination.
Adverse reactions
Slight alteration of faecal consistency may be commonly observed post-vaccination.
Calves may uncommonly display a peak in temperature of at least 1.7°C two days after vaccination that resolves the next day without treatment.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
