Bupredine Multidose
Active substance
ATC code
Species
Dogs, cats and horses.
Indications
Dog and cat: post-operative analgesia.
Horse: post-operative analgesia, in combination with sedation.
Dog and horse: potentiation of the sedative effects of centrally acting agents.
Dose to be administered and administration route
|
Species and route |
Post-Operative Analgesia |
Potentiation of Sedative Effects |
|
Dog: Intramuscular or intravenous injection |
10 - 20 μg/kg* (0.3 - 0.6 ml product per 10 kg) repeated if necessary after 3 - 4 hours with 10 μg/kg or 5 - 6 hours with 20 μg/kg doses |
10 - 20 μg/kg (0.3 - 0.6 ml product per 10 kg) |
|
Cat: Intramuscular or intravenous injection |
10 - 20 μg/kg (0.3 - 0.6 ml product per 10 kg) repeated once if necessary after 1 – 2 hours |
-- |
|
Horse: Intravenous injection |
10 μg/kg (3.3 ml product per 100 kg) 5 minutes after administration of an iv sedative. The dose may be repeated once, if necessary, after not less than 1-2 hours, in combination with intravenous sedation. |
5 μg/kg (1.7 ml product per 100 kg) 5 minutes after administration of an iv sedative, repeated if necessary after 10 minutes. |
*) The dosages expressed in μg/kg in the table above refer to buprenorphine (as hydrochloride). The kg in the table refers to body weight.
When used in horses, an intravenous sedative must be administered within five minutes prior to injection of buprenorphine.
In dogs, sedative effects are present by 15 minutes after administration.
Analgesic activity may not develop fully until 30 minutes. To ensure that analgesia is present during surgery and immediately on recovery, the product should be administered preoperatively as part of premedication. When administered for potentiation of sedation or as part of premedication, the dose of other centrally-acting agents, such as acepromazine or medetomidine, should be reduced. The reduction will depend on the degree of sedation required, the individual animal, the type of other agents included in premedication and how anaesthesia is to be induced and maintained. It may also be possible to reduce the amount of inhalational anaesthetic used.
Animals administered opioids possessing sedative and analgesic properties may show variable responses. Therefore, the response of individual animals should be monitored and subsequent doses should be adjusted accordingly. In some cases, repeat doses may fail to provide additional analgesia. In these cases, consideration should be given to using a suitable injectable NSAID.
An appropriately graduated syringe must be used to allow accurate dosing.
The closure must not be punctured more than 100 times (with a 21G or 23G needle).
Adverse reactions
Salivation, bradycardia, hypothermia, agitation, dehydration and miosis can occur in the dog, and rarely hypertension and tachycardia.
Mydriasis and signs of euphoria (excessive purring, pacing, rubbing) commonly occur in cats and will usually resolve within 24 hours.
In horses, use of buprenorphine without the prior use of a sedative agent can cause excitement and spontaneous locomotor activity
Buprenorphine may occasionally cause respiratory depression; refer to section 4.5. In horses, when used as directed in conjunction with sedatives or tranquillisers, excitation is minimal but ataxia may occasionally be marked. Buprenorphine may reduce gastrointestinal motility in horses but colic is rarely reported.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Dispensing
POM-V
| PRICE | Only for registered vets. Create a free profile to access all features.. Login |
|---|---|
| Art. Nr. | 41821/4027 |
| EAN | 8718469445363 |
Similar products
Showing 6 of 6 results
Bupredine Multidose
Bupredine Multidose
Bupredine Multidose
Bupredine Multidose
Bupredine Multidose
