Enurace 50
Active substance
ATC code
Species
Dog (ovariohysterectomised female dogs).
Indications
Treatment of urinary incontinence caused by urethral sphincter mechanism incompetence in ovariohysterectomised female dogs.
Dose to be administered and administration route
For oral administration only.
A starting dose of 2 mg ephedrine HCl per kg of bodyweight per day, divided in two oral doses is recommended. Dogs can be dosed according to the following table:
Weight (kg) | Dose (mg/day) | Dose (Number of tablets) | ||
per day | 1st gift | 2nd gift | ||
20-30 | 50 | 1 | ½ | ½ |
31-40 | 75 | 1 ½ | ½ | 1 |
41-50 | 100 | 2 | 1 | 1 |
Desired therapeutic effect and occurrence of adverse effects have to be monitored approximately at
14 days, 1 month, 3 months and 6 months after the start. Based on the observed effect in comparison with the expected effect and taking into account the occurrence of adverse effects, the individual dose should be adjusted. The dose should be adjusted to find the lowest effective dose.
Once the effective dose has been established, dogs should still be monitored at regular intervals, e.g. every six months.
The product should be administered before meals in a piece of food.
A maximum dose of 5 mg/ kg of bodyweight per day has to be respected.
Adverse reactions
• Cardiovascular effects like tachycardia, atrial fibrillation, stimulation of the heart activity; and vasoconstriction.
• Stimulation of the central nervous system leading to sleeplessness, excitation, anxiety and muscle tremors.
• Panting.
• Mydriasis.
• Cystitis.
• Bronchodilatation and decrease of mucus release in the respiratory mucosal membranes.
• Reduction of the motility and tone of the intestinal wall.
Due to the nature of ephedrine the mentioned effects can occur at the recommended therapeutic dose, with anxiety and cardiovascular effects being the most prevalent. In 10% of the treatments, side effects have been observed in efficacy studies.
Vomiting has been reported very rarely in spontaneous reports.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Dispensing
POM-V
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| Art. Nr. | |
| EAN | 5420045703073 |
