Alpha Ject micro 1 PD
Active substance
ATC code
Species
Atlantic salmon (Salmo salar L) with a minimum weight of 28 g.
Indications
For active immunisation of Atlantic salmon to reduce mortality, lesions in the heart and pancreas, and impaired growth caused by Pancreas Disease (PD).
Onset of immunity: 516 degree days.
Duration of immunity: at least 12 months.
Dose to be administered and administration route
Posology
A single dose of 0.05 ml per fish.
Administration route
The vaccine will be administered by intraperitoneal (i.p) injection. The fish should be anaesthetised prior to injection. It is recommended to starve the fish for a minimum of 48 hours before vaccination.
The vaccine should be left to slowly reach 15 – 20 °C by keeping it at room temperature. The vaccine should not be used if the vaccine shows signs of a brownish water phase in the bottom of the container. Contact the distributor for further advice. The vaccine should be well shaken prior to use by squeezing and shaking for approx. 2 minutes. Only administer if the vaccine appears as a homogenous, white to cream coloured emulsion.
To reduce the risk of adverse reactions, it is important to deposit the entire dose into the abdominal cavity. The injection needle used should have appropriate length to penetrate the abdominal wall by 1 – 2 mm. The entire needle should be inserted into the midline about one fin length anterior to the base of the pelvic fin.
The injection devices used for vaccination, i.e. automatic vaccination machines or manual syringes, must be designed and suitable for administration of the recommended dose volume in the target species. The devices must be operated by trained personnel and should be calibrated according to the manufacturers´ recommendation prior to use. Special care should be taken to ensure air is removed from the injection equipment (chambers and tubes) prior to vaccination. Regular dose controls (number of injections per bag) are recommended.
Adverse reactions
Melanisation and vaccine residues are very commonly observed in the abdominal cavity after vaccination. Mild visceral adhesions (corresponding to Speilberg scores 1 – 2) are very common, moderate adhesions (corresponding to Speilberg scores 3) are common, while the occurrence of severe adhesions (corresponding to Speilberg score ≥ 4) is very rare.
Spinal deformities of the so-called “cross-stitch vertebrae” type, have been commonly reported after the use of Alpha Ject micro 1 PD, primarily in fish put at sea in the autumn (S0-generation). These deformities are believed to have multifactorial causes and are possibly linked to the vaccine’s PD component. However, a causal relationship has not been proven.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
