Sedastop vet.
Active substance
ATC code
Species
Dogs and cats
Indications
Atipamezole hydrochloride is indicated for reversal of the sedative effects and cardiovascular effects after use of alpha-2- agonists like medetomidine and dexmedetomidine in dogs and cats.
Dose to be administered and administration route
For single intramuscular use.
Atipamezole hydrochloride is administered 15-60 min after medetomidine or dexmedetomidine hydrochloride administration.
Dogs: the intramuscular atipamezole hydrochloride dose [in µg] is five times that of the previous medetomidine hydrochloride dose or ten times that of the dexmedetomidine hydrochloride dose. Due to the 5-fold higher concentration of the active ingredient (atipamezole hydrochloride) in this product compared to that of preparations containing 1 mg medetomidine hydrochloride per ml and the 10-fold higher concentration compared to that of preparations containing 0.5 mg dexmedetomidine hydrochloride, an equal volume of each preparation is required.
Dosage example Dogs:
Medetomidine 1 mg/ml solution for injection dosage | Narcostop 5 mg/ml solution for injection for dogs dosage |
0.04 ml/kg body weight (bw), i.e. 40 µg/kg bw | 0.04 ml/kg bw, i.e. 200 µg/kg bw |
Dexmedetomidine 0.5 mg/ml solution for injection dosage | Narcostop 5 mg/ml solution for injection for dogs dosage |
0.04 ml/kg body weight (bw), i.e. 20 µg/kg bw | 0.04 ml/kg bw, i.e. 200 µg/kg bw |
Cats: the intramuscular atipamezole hydrochloride dose [in µg] is two-and-ahalf times that of the previous medetomidine hydrochloride dose or five times that of the dexmedetomidine hydrochloride dose. Due to the 5-fold higher concentration of the active ingredient (atipamezole hydrochloride) in this product compared to that of preparations containing 1 mg medetomidine hydrochloride per ml and the 10-fold higher concentration compared to that of preparations containing 0.5 mg dexmedetomidine hydrochloride, half the volume of the product to that of the previously administered medetomidine or dexmedetomidine should be given.
Dosage example Cats:
Medetomidine 1 mg/ml solution for injection dosage | Narcostop 5 mg/ml solution for injection for cats dosage |
0.08 ml/kg body weight (bw), i.e. 80 µg/kg bw | 0.04 ml/kg bw, i.e. 200 µg/kg bw |
Dexmedetomidine 0.5 mg/ml solution for injection dosage | Narcostop 5 mg/ml solution for injection for cats dosage |
0.08 ml/kg body weight (bw), i.e. 40 µg/kg bw | 0.04 ml/kg bw, i.e. 200 µg/kg bw |
The recovery time is shortened to approximately 5 minutes. The animal becomes mobile after approximately 10 minutes after administration of the product.
Adverse reactions
A transient hypotensive effect has been observed during the first 10 minutes post- injection of atipamezole hydrochloride. In rare cases hyperactivity, tachycardia, salivation, atypical vocalization, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination and uncontrolled defecation may occur.
In very rare cases recurrence of sedation may occur or the recovery time may not be shortened after administration of atipamezole.
In cats, when using low doses to partially reverse the effects of medetomidine or dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be guarded against.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).”
Dispensing
POM-V
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|---|---|
| Art. Nr. | 19994/4014 |
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