Myorelax
Active substance
ATC code
Species
Horses.
Indications
Induction of muscle relaxation and immobilisation, as an adjunct to balanced anaesthesia.
Depending on the procedure, guaifenesin can be used in combination with different anaesthetics:
- in combination with a sedative, and local anaesthetics for short procedures
- in combination with appropriate general anaesthetics, for induction and/or maintenance of muscle relaxation during anaesthesia.
Dose to be administered and administration route
For intravenous administration by catheter.
Dose: 100 mg guaifenesin per kg body weight per infusion, equivalent to 100 ml solution per 100 kg body weight.
Guaifenesin can be used in combination with different anaesthetics, as follows:
Local anaesthetics for short procedures:
Once the horse is properly sedated, guaifenesin is administered by rapid infusion until the animal lies down. A local anaesthetic should be used for painful procedures. Additional guaifenesin can be infused when the horse is recumbent, if needed.
General anaesthetics:
- Induction and short term maintenance of anaesthesia:
Pre-medication with an α-2 receptor agonist (e.g. xylazine, detomidine or romifidine) or acepromazine. If guaifenesin is to be administered with ketamine, pre-medication with one of the α-2 receptor agonists is recommended. Guaifenesin is administered by rapid infusion until the animal begins to sway on its feet. At this stage either ketamine, thiopental or propofol is administered at a bolus dose. The duration of action of these combinations is variable depending on the animal and the other drugs administered.
Surgical anaesthesia will be approximately 10-20 minutes duration and recumbency will be approximately 30-40 minutes duration.
- Maintenance of anaesthesia for medium duration procedures:
Guaifenesin, administered by continuous IV infusion (50-100 mg/kg) at an infusion rate of approximately 1 ml/kg/h, can be used as part of total intravenous anaesthesia (TIVA) in combination with other injectable anaesthetics for procedures lasting up to 1 hour.
- Volatile anaesthetics:
Guaifenesin can be used as an adjunct to balanced anaesthesia using volatile anaesthetics for longer procedures.
Guidance on anaesthetic protocols and doses of individual veterinary medicinal products can be found in veterinary textbooks and scientific literature. For safe use with other pharmaceuticals, reference must be made to the relevant product literature.
Adverse reactions
Horses:
|
Undetermined frequency (cannot be estimated from the available data): |
Hypotension, Thrombophlebitisa, Injection site reactionb |
a due to irritative properties. To reduce the incidence of thrombophlebitis, the catheter can be flushed with heparinised saline.
b extravascular reactions have been reported; the use of an intravenous catheter and careful technique will help prevent such occurrences.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. Seethe package leaflet for respective contact details.
Dispensing
POM-V
| PRICE | Only for registered vets. Create a free profile to access all features.. Login |
|---|---|
| Art. Nr. | 16849/5010 |
| EAN | 5701170451825 |
