CIDR OVIS
Active substance
ATC code
Species
Sheep (ewes).
Indications
For the induction and synchronization of oestrus and ovulation in non-cycling ewes during seasonal anoestrus.
For the induction and synchronization of oestrus and ovulation in cycling and in noncycling ewes for advancing the breeding season.
To be used in combination with eCG (equine chorionic gonadotrophin).
Dose to be administered and administration route
Vaginal use.
0.35 g of progesterone (1 device) per animal for 12 days.
One device should be inserted into the vagina of each ewe to be treated. The vaginal insert should be left in position for 12 days followed by an injection of equine Chorionic Gonadotrophin (eCG, formerly known as PMSG) administered at device removal. The onset of oestrus occurs within 1-2 days after removal of the insert.
In a study of 11 Lacaune breed ewes, ovulation occurred between 42 and 58 hours following eCG injection, with the majority (73%) ovulating between 50 and 54 hours. In the case that artificial insemination and advanced breeding techniques (e.g. embryo transfer) are applied, the timing of ovulation should be taken into consideration for the selected technique for optimal results.
Administration
A device applicator should be used for administration, following the procedure described below:
1. Ensure that the applicator is clean and dipped in a non-irritant antiseptic solution before use.
2. Wearing sterile disposable plastic gloves, fold the arms of the device and load into the applicator. The arms of the device should protrude slightly from the end of the applicator. Care should be taken to avoid unnecessary or prolonged handling of the product to minimise transfer of the active substance to the operator's gloves.
3. Apply a small quantity of obstetrical lubricant to the end of the loaded applicator.
4. Lift the tail and clean the vulva and perineum.
5. Gently insert the applicator into the vagina, first in a vertical direction and then horizontally until some resistance is encountered.
6. Make sure the removal string is free, press the handle of the applicator and allow the barrel to move back towards the handle. This releases the arms of the device, which will then retain the device in the anterior vagina.
7. With the device correctly positioned, withdraw the applicator, leaving the removal string exiting from the vulva.
The applicator should be cleaned and disinfected before being used on another animal.
Removal
The device may be removed by gently pulling on the tail. On occasions the tail of the device may not be visible from the outside of the animal, in such cases it may be located in the posterior vagina using a gloved finger. Approximately 1 in 10 devices may be lost by an animal. Withdrawal of the device should not require force. If any resistance is encountered a gloved finger should be used to ease removal.
If there is any difficulty in removal from the animal beyond that itemised above veterinary advice must be sought.
The device is intended for single use only.
Adverse reactions
Local irritation and discharge of cloudy/yellow mucus are common and discharge of dark red/brown mucus or mucus with fresh blood is uncommon. However, these signs typically resolve within 2 days of removal of the device without the need for treatment.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
