Alpha Ject micro 6
Active substance
ATC code
Species
Atlantic salmon (Salmo salar) of a minimum weight of 25 g.
Indications
For active immunisation of Atlantic salmon to reduce mortality caused by infections with Aeromonas salmonicida (furunculosis), Vibrio salmonicida (coldwater vibriosis), Listonella anguillarum serotype O1and O2a (classical vibriosis), Moritella viscosa (winter sore) and IPNV (infectious pancreatic necrosis).
| Onset of immunity: |
520 degree days post vaccination for the bacterial antigens and 600 degree days post vaccination for IPNV. |
| Duration of immunity: | 12 months for the bacterial antigens and 5.5 months for IPNV. |
Dose to be administered and administration route
Posology
Administer a single dose of 0.05 ml per fish. Fish should not be vaccinated more than once.
Administration route
The vaccine should be administered by intraperitoneal (i.p) injection into the midline about one fin length anterior to the base of the pelvic fin. To reduce the risk of adverse reactions, it is important to deposit the entire dose in the abdominal cavity. The injection needle used should have appropriate length to penetrate the abdominal wall and 1-2 mm into the abdominal cavity.
It is recommended to starve the fish for a minimum of 48 hours before vaccination.
The fish should be anaesthetised prior to injection.
Let the vaccine slowly reach 15-20°C by keeping it at room temperature.
Ensure a homogenous emulsion prior to use by squeezing and shaking the vaccine bag for approx. 2 minutes.
Only administer the vaccine if it appears as a homogenous, white to cream coloured emulsion.
The vaccine should not be used if the vaccine shows signs of a brownish water phase in the bottom of the container. Contact the distributor for further advice.
The injection devices used for vaccination, i.e. automatic vaccination machines or manual syringes, must be designed and suitable for administration of the recommended dose volume in the target species. The devices must be operated by trained personnel and should be calibrated according to the manufacturers' recommendation prior to use. Special care should be taken to ensure air is removed from the injection equipment (chambers and tubes) prior to vaccination. Regular dose controls are recommended.
The vaccination equipment should be thoroughly cleaned / sterilized before use.
Adverse reactions
The frequency of adverse reactions observed after vaccination in laboratory studies and field trials:
|
Very common |
Melanisation in the abdominal cavity |
|
Mild visceral adhesions (Speilberg score 1-2) |
|
|
Common |
Moderate visceral adhesions (Speilberg score 3) |
|
Very rare |
Serious visceral adhesions (Speilberg score ≥ 4) |
The severity of adverse reactions may be influenced by different factors such as sanitation, vaccination technique, fish size at vaccination and water temperature during vaccination and in the first 6-12 weeks after vaccination. As a general precaution it is recommended to perform vaccination at water temperature of 15 °C or below.
Small fish and high water temperature may increase the severity of adverse reactions.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
