Bupaq Multidose vet.
Active substance
ATC code
Species
Dogs and cats
Indications
DOG
Post-operative analgesia.
Potentiation of the sedative effects of centrally-acting agents.
CAT
Post-operative analgesia.
Dose to be administered and administration route
For intramuscular or intravenous use.
DOG: Post-operative analgesia, potentiation of the sedation
CAT: Post-operative analgesia
10 - 20 micrograms per kg (0.3 - 0.6 ml per 10 kg)
For further pain relief the dose may be repeated if necessary:
DOG: either after 3 - 4 hours with 10 µg/kg or after 5 - 6 hours with 20 µg/kg.
CAT: Once, after 1 - 2 hours with 10 - 20 µg/kg.
While sedative effects are present by 15 minutes after administration, analgesic activity becomes apparent after approximately 30 minutes. To ensure that analgesia is present during surgery and immediately on recovery, the product should be administered preoperatively as part of premedication.
When administered for potentiation of sedation or as part of premedication, the dose of other centrally-acting agents, such as acepromazine or medetomidine, should be reduced. The reduction will depend on the degree of sedation required, the individual animal, the type of other agents included in premedication and how anaesthesia is to be induced and maintained. It may also be possible to reduce the amount of inhalational anaesthetic used.
Animals administered opioids possessing sedative and analgesic properties may show variable responses. Therefore, the response of individual animals should be monitored and subsequent doses should be adjusted accordingly. In some cases, repeat doses may fail to provide additional analgesia. In these cases, consideration should be given to using a suitable injectable NSAID.
Before administration, the weight of the animal should be accurately determined. An appropriately graduated syringe must be used to allow accurate dosing.
The rubber stopper can be punctured a maximum of 25 times.
Adverse reactions
Salivation, bradycardia, hypothermia, agitation, dehydration and miosis can occur in the dog, and rarely hypertension and tachycardia.
Mydriasis and signs of euphoria (excessive purring, pacing, rubbing) commonly occur in cats and will usually resolve within 24 hours.
Buprenorphine may cause respiratory depression (refer to section 4.5). When used to provide analgesia, sedation is rarely seen, but may occur at dose levels higher than those recommended.
Local discomfort or pain at the injection site, resulting in vocalisation, may occur very rarely*. The effect is normally temporary.
*The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports)
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Art. Nr. | 57446/4001 |