DogStem
Active substance
ATC code
Species
Dogs
Indications
Improvement in function, reduction of pain and lameness associated with mild to severe osteoarthritis in hip and elbow joints.
Dose to be administered and administration route
Route of administration:
Intraarticular use.
Posology:
A single intraarticular injection of 1 ml (6.5x106 - 9x106 equine umbilical cord mesenchymal stem cells) into the affected joint.
Method of administration:
The veterinary product must be administered intraarticularly, only by a veterinary surgeon, taking special precautions to ensure the sterility of the injection process. The product must be handled and injected following sterile techniques and in a clean environment.
Swirl gently before use in order to ensure the contents are well mixed.
Use a 23G needle.
Intraarticular placement should be confirmed by the appearance of synovial fluid in the hub of the needle.
The use of a single dose of systemic NSAIDs is recommended on the day of product administration
Adverse reactions
Lameness and pain (mild to severe) was reported very commonly within 24 hours after product administration. Lameness and pain with a delayed onset (≤1 week post-treatment) was also observed commonly. Resolution of lameness and pain depended on the severity. Mild lameness and pain resolved completely within a few days without the need for anti-inflammatory treatment. Severe lameness and pain required symptomatic treatment with non-steroidal anti-inflammatory drugs (NSAIDs) and complete remission took a period of weeks
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
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