Ziapam
Active substance
ATC code
Species
Dog and cat.
Indications
For the short term management of convulsive disorders and skeletal muscle spasms of central and peripheral origin.
As part of a pre-anaesthetic or sedation protocol.
Dose to be administered and administration route
For administration by slow, intravenous injection only.
In dogs and cats:
Short term management of convulsive disorders: 0.5 mg diazepam/kg bodyweight (equivalent to 0.5 ml/5kg).
Administered as a bolus and repeated up to three times, after no less than 10 minutes each time.
Short term management of skeletal muscle spasm: 0.5-2.0 mg/kg bodyweight (equivalent to 0.5-2.0 ml/5kg).
As part of sedation protocol: 0.2-0.6 mg/kg bodyweight (equivalent to 0.2-0.6 ml/5kg).
As part of pre-anaesthesia protocol: 0.1-0.2 mg/kg bodyweight (equivalent to 0.1-0.2 ml/5kg).
Adverse reactions
Dogs and cats:
|
Rare (1 to 10 animals / 10,000 animals treated): |
Behavioural disorders (e.g. excitation, aggression, desinhibiting effect)1 |
|
Very rare (<1 animal / 10,000 animals treated, including isolated reports): |
Hepatic necrosis (acute) 2, liver failure 2 |
|
Undetermined frequency: |
Hypotension 3, cardiac disorders 3, and thrombophlebitis 3 |
1 Paradoxical reactions. Mainly in small breeds of dogs. Avoid use of diazepam as a sole agent in potentially aggressive animals.
2 In cats only.
3 May be caused by rapid intravenous administration.
4 Mainly in cats.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See also the last section of the package leaflet for contact details.
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