PropoFlo Plus
Active substance
ATC code
Species
Dogs and cats.
Indications
The veterinary medicinal product is indicated for therapeutic use in dogs and cats as a short-acting, intravenous general anaesthetic with a short recovery period:
For procedures of short duration, lasting up to approximately 5 minutes.
For induction of general anaesthesia where maintenance is provided by inhalation anaesthetic agents.
For induction and short-term maintenance of general anaesthesia by administration of incremental doses of the product to effect for approximately half an hour (30 minutes), not to exceed the total dose stated in section 4.3.
Dose to be administered and administration route
The veterinary medicinal product is a sterile product for intravenous administration.
General handling procedures
Prior to use, the product should be inspected visually for absence of particulate matter and discolouration and discarded if present.
Shake the vial gently but thoroughly before opening. See sections 4.4 and 6.3.
Dosage for Induction
The induction dose is calculated according to bodyweight and may be administered to effect over a period of 10-40 seconds. See section 4.4. The use of preanaesthetic drugs may markedly reduce propofol requirements. As with other sedative hypnotic agents, the amount of opioid, α-2 agonist and/or benzodiazepine premedication will influence the response of the patient to an induction dose of the product.
Where animals have been premedicated with an α-2 agonist such as medetomidine, the dose of propofol (as with any other intravenous anaesthetic agent) should be reduced by up to 85% (e.g. from 6.5 mg/kg for unpremedicated dogs to 1.0 mg/kg for dogs premedicated with an α-2 agonist).
The average induction dose for dogs and cats, either unpremedicated or when premedicated with a non-α-2 agonist tranquilliser such as acepromazine, is given in the following table.
These doses are for guidance only; the actual dose should be based on the response of the particular animal. See section 4.3.
Dosage for Maintenance
When anaesthesia is maintained by incremental injections, the dose rate will vary between animals. Administer incremental doses of the product to effect by giving small doses of around 0.1 ml/kg bodyweight (1.0 mg/kg bodyweight) of the induction dose when anaesthesia becomes too light. These doses may be repeated as often as required, allowing 20-30 seconds to assess the effect before further increments are given.
Experience has shown that doses of approximately 1.25-2.5 mg (0.125-0.25 ml) per kg bodyweight sustain anaesthesia for periods of up to 5 minutes.
Continuous and prolonged exposure (greater than 30 minutes) may lead to slower recovery, particularly in cats. See section 4.3 and 4.10.
Maintenance by inhalation agents
When inhalation agents are used to maintain general anaesthesia, experience indicates that it may be necessary to use a higher initial concentration of the inhalant anaesthetic than is usually required following induction with barbiturate agents such as thiopentone.
Adverse reactions
Side-effects during induction, maintenance and recovery are uncommon. As with other anaesthetic agents, the possibility of respiratory or cardiovascular depression should be considered. During induction of anaesthesia, very rarely, mild hypotension and transient apnoea may occur. See section 4.5. Induction is generally smooth, with evidence of excitation (paddling of limbs, nystagmus, focal muscle twitching, opisthotonus) reported in very rare cases. During the recovery phase, emesisand excitation have been observed very rarely in a small proportion of animals.
In clinical trials in cats and dogs, transient apnoea has been observed during induction. In cats sneezing, occasional retching and a paw/face licking characteristic during recovery have been observed in a small proportion of cases.
If panting is present before induction, it may continue throughout the subsequent periods of anaesthesia and recovery.
In very rare cases, inadvertent perivascular administration causes local tissue reactions.
Repeated anaesthesia with propofol in cats may cause oxidative injury and Heinz body production. Recovery may also become prolonged. Limiting repeated anaesthesia to intervals of more than 48 hours will reduce the likelihood.
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PropoFlo Plus
