CIDR
Active substance
ATC code
Species
Cattle (cows and heifers).
Indications
For the control of the oestrous cycle in cycling cows and heifers, including:
- Synchronisation of oestrus in groups of animals including fixed time artificial insemination (FTAI) programmes.
- Synchronisation of donor and recipient animals for embryo transfer.
To be used in combination with prostaglandin F2 α or analogue.
Use as recommended, normally results in oestrus 48-96 hours after device removal with the majority of animals showing oestrus within 48-72 hours.
For induction and synchronisation of oestrus in Fixed Time Artificial Insemination (FTAI) protocols:
- In cycling cows and heifers. To be used in combination with prostaglandin F2 α (PGF2α) or analogue.
- In cycling and non-cycling cows and heifers. To be used in combination with Gonadotrophin releasing hormone (GnRH) or analogue and PGF2α or analogue.
- In non-cycling cattle. To be used in combination with PGF2α or analogue and equine chorionic gonadotrophin (eCG).
Dose to be administered and administration route
Vaginal use.
1.38 g of progesterone (1 device) per animal for 7- 9 days (depending on indication).
For synchronisation of oestrus and synchronisation of donor and recipient animals for embryo transfer:
One device should be inserted into the vagina of each cow or heifer to be treated. The vaginal insert should be left in position for 7 days with an injection of a luteolytic dose of prostaglandin F2α or analogue administered 24 hours prior to removal. In animals that respond to treatment the onset of oestrus generally occurs within 1-3 days after removal of the insert. Cows should be inseminated within 12 hours of first observed oestrus.
For the induction and synchronisation of oestrus for Fixed Time Artificial Insemination (FTAI):
The following FTAI protocols have been commonly reported in the scientific literature and should be used:
In cycling cows and heifers:
- Insert one CIDR 1.38 g into vagina for 7 days.
- Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal. - FTAI 56 hours after removal of the device.
In cycling and non-cycling cows and heifers:
- Insert one CIDR 1.38 g into vagina for 7- 8 days.
- Inject a dose of GnRH or analogue at CIDR 1.38 g insertion.
- Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal.
- FTAI 56 hours after removal of the device, or
- Inject GnRH or analogue 36 hours after CIDR 1.38 g removal and FTAI 16 to 20 hours later.
In non-cycling cows:
The following FTAI protocol should be used:
- Insert one CIDR 1.38 g into vagina for 9 days.
- Inject a luteolytic dose of PGF2α or analogue 24 hours prior to device removal.
- Inject eCG at CIDR 1.38 g removal.
- FTAI 56 hours after removal of the device, or inseminate within 12 hours following first observed oestrus behaviour.
Administration:
A device applicator should be used for administration, following the procedure described below:
1. Ensure that the applicator is clean and dipped in a non-irritant antiseptic solution before use.
2. Wearing sterile disposable plastic gloves, fold the arms of the device and load into the applicator. The arms of the device should protrude slightly from the end of the applicator. Care should be taken to avoid unnecessary or prolonged handling of the veterinary medicinal product to minimise transfer of the active substance to the operator's gloves.
3. Apply a small quantity of obstetrical lubricant to the end of the loaded applicator.
4. Lift the tail and clean the vulva and perineum.
5. Gently insert the applicator into the vagina, first in a vertical direction and then horizontally until some resistance is encountered.
6. Make sure the removal string is free, press the handle of the applicator and allow the barrel to move back towards the handle. This releases the arms of the device, which will then retain the device in the anterior vagina.
7. With the device correctly positioned, withdraw the applicator, leaving the removal string hanging from the vulva.
8. The applicator should be cleaned and disinfected before being used on another animal.
Removal:
The device may be removed by gently pulling on the string. On occasions the string may not be visible from the outside of the animal, in such cases it may be located in the posterior vagina using a gloved finger. Withdrawal of the device should not require force. If any resistance is encountered a gloved hand should be used to ease removal.
If there is any difficulty in removal from the animal beyond that itemised above veterinary advice must be sought.
The device is intended for single use only.
Adverse reactions
Cattle (cows and heifers):
Very rare (<1 animal / 10,000 animals treated, including isolated reports): | vaginal discharge1, vulva irritation / vaginal irritation1 |
1 observed at removal of insert, this discharge generally clears between the time of removal and insemination and has not been seen to affect conception rates following treatment.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
