AceSedate
Active substance
ATC code
Species
Horses.
Indications
Anaesthetic Premedication: Following acepromazine administration, the amount of anaesthetic necessary to induce anaesthesia is considerably reduced. This reduction is approximately one-third of a suitable induction agent.
Tranquilisation: Acepromazine tranquilisation (ataraxy) involves a modification of temperament which is not associated with hypnosis, narcosis or marked sedation. This is achieved with low doses of acepromazine. At low doses, acepromazine reduces anxiety which is beneficial for use in horses prior to shoeing or transportation.
Sedation: At higher dose rates acepromazine is an effective sedative, as an adjunct to, or replacement for, physical restraint e.g. dentistry, handling and shoeing. The relaxant effects aid examination of the penis in horses and the treatment of tetanus and choke.
Dose to be administered and administration route
By intramuscular injection: 0.03 - 0.10 mg per kg bodyweight. Approximately equivalent to 0.15 - 0.5 ml of 10 mg/ml injection per 50 kg (approx. 1 cwt) bodyweight.
By intravenous injection: As for intramuscular, except that it is recommended the injection is made slowly.
Normally, single doses of acepromazine are administered. Long term use is not recommended. On the rare occasions that repeat dosing is required, the dosing interval should be 36 - 48 hours.
Take adequate precautions to maintain sterility. Avoid the introduction of contamination during use. Should any apparent growth or discolouration occur, discard the product.
The closure may be safely punctured up to 38 times.
Adverse reactions
Acepromazine has caused paraphimosis, sometimes as a sequel to priapism. When extrusion of the penis occurs, the owner should be advised to inform his veterinary surgeon if retraction of the penis does not take place within 2 - 3 hours. Suitable treatments have been described in the veterinary literature e.g. manual compression during the period of general anaesthesia, penile support and manual compression, use of an Esmarch bandage.
Accidental intracarotid injection in horses can produce clinical signs ranging from disorientation to convulsive seizures and death.