Buprelieve Multidose
Active substance
ATC code
Species
Dogs, cats and horses
Indications
Post-operative analgesia in the dog, cat and horse.
Potentiation of the sedative effects of centrally-acting agents in the dog and horse.
When used in horses, an intravenous sedative should be administered within five minutes prior to injection of buprenorphine.
Dose to be administered and administration route
Administration:
Dog: intramuscular or intravenous injection
Cat: intramuscular or intravenous injection
Horse: intravenous injection
Species |
Route of Administration |
Post-Operative Analgesia |
Potentiation of Sedation |
Dog |
Intramuscular or intravenous injection |
10 - 20 micrograms per kg (0.3 - 0.6 ml per 10 kg). For further pain relief, repeat if necessary after 3 - 4 hours with 10 microgram per kg or 5 - 6 hours with 20 microgram per kg. |
10 - 20 micrograms per kg (0.3 - 0.6 ml per 10 kg). |
Cat |
Intramuscular or intravenous injection |
10 - 20 microgram per kg (0.3 - 0.6 ml per 10 kg). Repeated if necessary, once, after 1 - 2 hours. |
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Horse |
Intravenous injection |
10 microgram per kg (3.3 ml per 100 kg), 5 minutes after administration of an iv sedative. The dose may be repeated if necessary, once, after not less than 1 - 2 hours |
5 micrograms per kg (1.7 ml per 100 kg), 5 minutes after administration of an iv sedative. The dose may be repeated if necessary after 10 minutes |
In dogs, sedative effects are present by 15 minutes after administration. Analgesic activity may not develop fully until 30 minutes. To ensure that analgesia is present during surgery and immediately on recovery, the product should be administered preoperatively as part of premedication.
When administered for potentiation of sedation or as part of premedication, the dose of other centrally-acting agents, such as acepromazine or medetomidine, should be reduced. The reduction will depend on the degree of sedation required, the individual animal, the type of other agents included in premedication and how anaesthesia is to be induced and maintained. It may also be possible to reduce the amount of inhalational anaesthetic used.
Animals administered opioids possessing sedative and analgesic properties may show variable responses. Therefore, the response of individual animals should be monitored and subsequent doses should be adjusted accordingly. In some cases, repeat doses may fail to provide additional analgesia. In these cases, consideration should be given to using a suitable injectable NSAID.
An appropriately graduated syringe must be used to allow accurate dosing.
Adverse reactions
Salivation, bradycardia, hypothermia, agitation, dehydration and miosis can occur in the dog, and rarely hypertension and tachycardia.
Mydriasis and signs of euphoria (excessive purring, pacing, rubbing) commonly occur in cats and will usually resolve within 24 hours.
Buprenorphine may cause respiratory depression. (refer to section 4.5)
When used to provide analgesia in horses, sedation is rarely seen, but may occur at dose levels higher than those recommended. When used in conjunction with sedatives or tranquillisers, excitation is normally minimal, but ataxia may occasionally be marked. Colic is rarely reported.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).