Rimadyl vet.
Active substance
ATC code
Species
Canine and feline.
Indications
| Dogs: | For the control of post-operative pain and inflammation following orthopaedic and soft tissue (including intra-ocular) surgery. |
| Cats: | For the control of post-operative pain following surgery. |
Dose to be administered and administration route
| Dogs: | The recommended dosage is 4.0 mg/kg bodyweight (1 ml/12.5kg bodyweight), by intravenous or subcutaneous injection, best given preoperatively, either at the time of premedication or induction of anaesthesia. To extend analgesic and anti-inflammatory cover postoperatively, parenteral therapy may be followed with Rimadyl tablets at 4mg/kg/day for up to 5 days. |
| Cats: | The recommended dosage is 4 mg/kg (0.24ml/3.0kg bodyweight) by subcutaneous or intravenous injection, best given pre-operatively at the time of induction of anaesthesia. Due to the longer half life in cats and narrower therapeutic index particular care should be taken not to exceed the recommended dose and the use of a 1 ml graduated syringe is recommended to measure the dose accurately. |
Clinical trial evidence in dogs and cats suggests only a single dose of carprofen is required in the first 24 hours peri-operatively; if further analgesia is required within this period, a single half dose (2 mg/kg) of carprofen may be given to dogs (but not cats) as necessary.
Adverse reactions
Typical undesirable effects associated with NSAIDs such as vomiting, soft faeces/diarrhoea, faecal occult blood, loss of appetite and lethargy have been reported. These adverse reactions are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal. If adverse reactions occur, use of the product should be stopped and the advice of a veterinarian should be sought. As with other NSAIDs there is a risk of rare renal, idiosyncratic hepatic or gastro-intestinal tract adverse events.
Rarely reactions at the injection site may be observed following subcutaneous injection.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
Dispensing
POM-V - Prescription Only Medicine – Veterinarian
TRUSTED SOURCE
SUMMARY OF PRODUCT CHARACTERISTICS
1. NAME OF THE VETERINARY MEDICINAL PRODUCT
Rimadyl Small Animal Solution for Injection 50 mg/ml
2. QUALITATIVE AND QUANTITATIVE COMPOSITION
Active Ingredient: mg/ml
Carprofen 50.0
Preservative:
Benzyl Alcohol 10.0
For the full list of all other excipients see section 6.1
3. PHARMACEUTICAL FORM
Solution for injection.
A clear, pale yellow solution.
4. CLINICAL PARTICULARS
4.1 Target species
Canine and feline.
4.2 Indications for use, specifying the target species
Dogs: For the control of post-operative pain and inflammation following orthopaedic and soft tissue (including intra-ocular) surgery.
Cats: For the control of post-operative pain following surgery.
4.3 Contraindications
Do not administer by intra-muscular injection.
Do not exceed the stated dose or the duration of treatment.
Do not use in animals suffering from cardiac, hepatic or renal disease, where there is a possibility of gastro-intestinal ulceration or bleeding hypersensitivity to the product.
Do not administer other NSAIDs concurrently or within 24 hours of each other. Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs, which can lead to toxic effects.
4.4 Special warnings for each target species
None.
4.5 Special precautions for use
Special precautions for use in animals
Use in any animal less than 6 weeks of age, or in aged animals, may involve additional risk. If such a use cannot be avoided, animals may require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive animal, as there is a potential risk of increased renal toxicity.
Concurrent administration of potential nephrotoxic drugs should be avoided.
NSAID’s can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Avoid contact with skin and eyes. Wash off any splashes immediately with clean, running water. Seek medical attention if irritation persists.
Care should be taken to avoid self-injection. If accidental self-injection occurs, seek medical attention immediately.
4.6 Adverse reactions (frequency and seriousness)
Typical undesirable effects associated with NSAIDs such as vomiting, soft faeces/diarrhoea, faecal occult blood, loss of appetite and lethargy have been reported. These adverse reactions are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal. If adverse reactions occur, use of the product should be stopped and the advice of a veterinarian should be sought. As with other NSAIDs there is a risk of rare renal, idiosyncratic hepatic or gastro-intestinal tract adverse events. Rarely reactions at the injection site may be observed following subcutaneous injection.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
4.7 Use during pregnancy, lactation or lay
In the absence of any specific studies in pregnant target animals, such use is not indicated.
4.8 Interaction with other medicinal products and other forms of interaction
No significant drug interactions have been reported for carprofen. The acute toxicity of carprofen in animals was not significantly affected in tests with fifteen commonly used (or commonly available) drugs. These were acetylsalicylic acid, amphetamine, atropine, chlorpromazine, diazepam, diphenhydramine, ethyl alcohol, hydrochlorothiazide, imipramine, meperidine, propoxyphene, penobarbital, sulfisoxazole, tetracycline and tolbutamide. (Jeunet, 1982).
Rimadyl Small Animal Solution for Injection should not be administered concurrently, or within 24 hours of another NSAID, or in conjunction with glucocorticosteroids.
Whilst carprofen and warfarin may both be bound to plasma proteins, they may be used concurrently provided the clinical situation is carefully monitored since it has been shown that they bind to two distinct sites on human and bovine serum albumin [Sudlow et al (1976), Crouthamel and Popick (1979) and Jeunet (1982)].
4.10 Amounts to be administered and administration route
Dogs: The recommended dosage is 4.0 mg/kg bodyweight (1 ml/12.5kg bodyweight), by intravenous or subcutaneous injection, best given preoperatively, either at the time of premedication or induction of anaesthesia. To extend analgesic and anti-inflammatory cover post-
operatively, parenteral therapy may be followed with Rimadyl tablets at 4mg/kg/day for up to 5 days.
Cats: The recommended dosage is 4 mg/kg (0.24ml/3.0kg bodyweight) by subcutaneous or intravenous injection, best given pre-operatively at the
time of induction of anaesthesia. Due to the longer half life in cats and narrower therapeutic index particular care should be taken not to exceed the recommended dose and the use of a 1 ml graduated syringe is recommended to measure the dose accurately.
Clinical trial evidence in dogs and cats suggests only a single dose of carprofen is required in the first 24 hours peri-operatively; if further analgesia is required within this period, a single half dose (2 mg/kg) of carprofen may be given to dogs (but not cats) as necessary.
4.11 Overdose (symptoms, emergency procedures, antidotes), if necessary
There is no specific antidote for carprofen overdosage but general supportive therapy, as applied to clinical overdosage with NSAID’s, should be applied.
4.11 Withdrawal period(s)
Not applicable.
5. PHARMACOLOGICAL PROPERTIES
Mechanism of Action
Carprofen is a member of the 2-arylpropionic acid group of non-steroidal antiinflammatory drugs (NSAIDs), and possesses anti-inflammatory, analgesic and antipyretic activity.
Carprofen, like most other NSAIDs is an inhibitor of the enzyme cyclooxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. At therapeutic doses in the dog, horse and cat, inhibition of the products of cyclo-oxygenase (prostaglandins and thromboxanes) or lipoxygenase (leucotrienes) has been absent or slight.
Since prostaglandin inhibition is thought to underlie the principal toxic side effects of NSAIDs, lack of cyclo-oxygenase inhibition may explain the excellent gastro-intestinal and renal tolerance of carprofen seen in these species. The precise mode of action of carprofen has not yet been fully elucidated.
6. PHARMACEUTICAL PARTICULARS
6.1 List of excipients
L Arginine
Glycocholic Acid
Lecithin (soya)
Sodium Hydroxide Pellets
Sodium Hydroxide
Benzyl Alcohol
Hydrochloric Acid
Water for Injections
6.2 Major Incompatibilities
None known.
6.3 Shelf-life
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Shelf life after first opening the immediate packaging: 28 days.
6.4 Special precautions for storage
Store in a refrigerator (2 to 8oC). Do not freeze. Once broached, the product is stable at temperatures up to 25oC for 28 days.
6.5 Nature and composition of immediate packaging
20ml multidose amber (Type 1) vial of approximately 20mm diameter, capped with a grey butyl rubber stopper and aluminium seal.
6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products, if appropriate
Any unused veterinary medicinal product or waste material derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
7. MARKETING AUTHORISATION HOLDER
Zoetis UK Limited
1st Floor, Birchwood Building
Springfield Drive
Leatherhead
Surrey
KT22 7LP
8. MARKETING AUTHORISATION NUMBER
Vm 42058/4123
9. DATE OF THE FIRST AUTHORISATION
04 February 1999
10. DATE OF REVISION OF THE TEXT
March 2023
Approved 01 March 2023
Compare packages
Rimadyl vet.
Rimadyl vet.
