Rominervin vet.
Active substance
ATC code
Species
Horses
Indications
Sedative to facilitate handling, examination, minor surgical interventions and minor procedures.
For premedication prior to administration of injectable or inhalation anaesthetics.
Romifidine can also be used with synthetic opiates (e.g. butorphanol) to provide deeper sedation/analgesia.
Dose to be administered and administration route
For intravenous use.
A dose range of 0.04 – 0.12 mg romifidine HCl/kg bodyweight (0.4 – 1.2 ml product/100 kg bodyweight) gives a dose-related response.
Onset of action, which is independent of dose, is 1 – 2 minutes. Maximum sedation is achieved after 5 - 10 minutes. Please see the Table below.
Recommended dose
Sedation
|
Dose |
Depth of Sedation |
Duration of Sedation |
|
0.04 mg romifidine HCl/kg bw (i.e. 0.4 ml product/100 kg bw) |
Light |
0.5 - 1 hour |
|
0.08 mg romifidine HCl/kg bw (i.e. 0.8 ml product/100 kg bw) |
Deep |
0.5 – 1.5 hours |
|
0.12 mg romifidine HCl/kg bw (i.e. 1.2 ml product/100 kg bw) |
Deep sedation of prolonged duration |
At this dose residual sedation may persist for up to 3 hours |
When romifidine is used in combination with butorphanol for deeper sedation and analgesia, a dose of 0.04 mg – 0.12 mg romifidine HCl/kg bw (0.4 – 1.2 ml product per 100 kg bw) should be used followed by butorphanol.
Premedication
Premedication with ketamine for induction
When romifidine is used as premedication prior to ketamine induced anaesthesia, a dose of 0.1 mg romifidine HCl/ kg bw (1 ml product/100 kg bw) should be used followed by ketamine after 5-10 minutes.
Premedication with other agents for induction
When romifidine is used as premedication in combination with other agents such as injectable or inhalation anaesthetics, a dose of 0.04 mg – 0.08 mg romifidine HCl/kg bw (0.4 – 0.8 ml product per 100 kg bw) should be used followed by induction of anaesthesia after 5-10 minutes.
Maintenance of anaesthesia
To maintain or deepen surgical anaesthesia with romifidine/ketamine, when facilities for gaseous anaesthesia are not available, romifidine can be administered at a dose of 0.025 mg/kg romifidine HCl (0.25 ml product/100 kg bodyweight) followed immediately by ketamine intravenously (50% of the initial ketamine premedication dose). Administer the romifidine/ketamine top-up dose immediately prior to commencement of surgical incision or when signs of returning consciousness appear.
The stopper should not be punctured more than 40 times
Adverse reactions
As with other veterinary medicinal products of this class, the following adverse events may occur:
- Bradycardia, which may be profound
- Benign, reversible cardiac arrhythmias (second degree AV block and to a lesser extent sino-atrial block)
- Hypotension, following a short period of hypertension
- Incoördination of the limbs/ataxia
- Sweating and increased salivation
- Hyperglycemia and diuresis
- In male horses, a reversible, partial penile prolapse can occur.
- Increased sensitivity of the hind legs (defensive movements)
- In very rare cases mild symptoms of colic, as the intestinal motility is temporarily inhibited.
Hypersensitivity may occur in very rare cases.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
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|---|---|
| Art. Nr. | 41821/4062 |
| EAN | 8718469443949 |
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