Prellim
Active substance
ATC code
Species
Cattle (cows) and pigs (sows).
Indications
Cattle (cows)
Indications for reproduction: synchronization or induction of oestrus. Induction of parturition.
Therapeutic indication: ovarian dysfunction (persistent corpus luteum, luteal cyst), interruption of pregnancy including foetal mummification, endometritis/pyometra, delayed uterine involution.
Pigs (sows)
Indications for reproduction: Induction of parturition.
Dose to be administered and administration route
For intramuscular use only:
Cattle(cows): The recommended dose is 0.150 mg d-cloprostenol/animal, equivalent to 2 ml/animal.
- Oestrus induction (also in cows with weak or silent heat): After determining the presence of corpus luteum (day 6-18 of the cycle), administer the veterinary medicinal product. Heat is generally observed in 48-60 hours. Inseminate 72-96 hours after this treatment. If heat is not observed, repeat after 11 days.
- Parturition induction: Administer the veterinary medicinal product after gestation day 270. Parturition should occur 30-60 hours post-treatment.
- Oestrus synchronisation: Administer the veterinary medicinal product twice (11 days apart). Inseminate artificially 72 and 96 hours after the second injection.
- Ovarian dysfunction: Once the presence of corpus luteum is determined, administer the veterinary medicinal product and inseminate in the first heat after the treatment. If no heat is observed, carry out a gynaecological examination again and repeat the injection 11 days after the first treatment. Insemination is 72-96 hours post-treatment.
- Endometritis or pyometra: Administer 1 dose of the veterinary medicinal product. Repeat the treatment 10-11 days later if necessary.
- Gestation interruption: Administer the veterinary medicinal product during the first half of gestation.
- Foetal mummification: Administer 1 dose of veterinary medicinal product. The foetus will be expelled after 3 or 4 days.
- Retarded uterine involution: Administer 1 dose of the veterinary medicinal product and, if indicated, repeat the treatment once or twice at 24 hours interval.
Pigs(sows): The recommended dose is 0.075 mg d-cloprostenol/animal, equivalent to 1 ml/animal.
- Parturition induction: Administer the veterinary medicinal product after day 112 of gestation. Repeat after 6 hours. Alternatively, 20 hours after the initial dose of d-cloprostenol, a myometrial stimulant (oxytocin or carazolol) may be administered. Following the protocol of double administration, in about 70% of cases, parturition occurs 20-30 hours after the first treatment.
Adverse reactions
Cattle and pigs
|
Very rare (< 1 animal / 10,000 animals treated, including isolated reports) |
Application site reaction1 Injection site swelling1 Injection site gaseous gangrene1 |
1Typical local reactions due to anaerobic infection applies in particular to cows.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See also the last section of the package leaflet for respective contact details.
