Acegon

Intramuscular use.

• Treatment of ovarian follicular cysts: 100-150 micrograms of gonadorelin (as acetate) per animal (i.e. 2- 3 ml of the product per animal). If necessary, treatment can be repeated at intervals of 1-2 weeks.

• In association with artificial insemination to optimise the time of ovulation, improving the chances that the treated cow will become fertile: 100 micrograms of gonadorelin (as acetate) per animal (i.e. 2 ml of the product per animal). It must be administered at the same time as artificial insemination and/or 12 days after this.

The following timing of injection and insemination should be followed:

- Injection should be performed between 4 and 10 hours after oestrus detection.

- An interval of at least 2 hours between the injection of GnRH and artificial insemination isrecommended.

- Artificial insemination should be carried out in accordance with the usual field recommendations,i.e., 12 to 24 hours after oestrus detection.

Induction and synchronisation of oestrus and ovulation in combination with prostaglandin F_2α (PGF_2α) with or without progesterone as part of Fixed Time Artificial Insemination (FTAI) protocols:

The following FTAI protocols have been commonly reported in the literature:

In cycling cows:

• Day 0 Inject 100 micrograms of gonadorelin (as acetate) per animal (2 ml of the product)

• Day 7 Inject PGF_2α or analogue (luteolytic dose)

• Day 9 Inject 100 micrograms of gonadorelin (as acetate) per animal (2 ml of the product)

• Artificial insemination 16–20 hours later, or at observed oestrus if sooner.

Alternatively:

• Day 0 Inject 100 micrograms of gonadorelin (as acetate) per animal (2 ml of the product)

• Day 7 Inject PGF_2α or analogue (luteolytic dose)

• Artificial insemination and injection of 100 micrograms of gonadorelin (as acetate) per animal (2 ml of the product) 60–72 hours later, or at observed oestrus if sooner.

In cycling and non-cycling cows and heifers:

• Insert intravaginal progesterone releasing device for 7-8 days.

• Inject 100 micrograms of gonadorelin (as acetate) per animal (2 ml of the product) at progesterone device insertion.

• Inject a luteolytic dose of PGF_2α or analogue 24 hours prior to device removal.

• FTAI 56 hours after removal of the device, or

• Inject 100 micrograms of gonadorelin (as acetate) per animal (2 ml of the product) 36 hours after progesterone releasing device removal and FTAI 16 to 20 hours later.