Alzane
Active substance
ATC code
Species
Dogs and cats.
Indications
Atipamezole hydrochloride is a selective α2-antagonist and indicated for reversal of the sedative effects of medetomidine and dexmedetomidine in dogs and cats.
Dose to be administered and administration route
. For single intramuscular use. The dose depends on the previously administered medetomidine or dexmedetomidine dose. Use of an appropriately graduated syringe is recommended to ensure accurate dosing when administering small volumes. Atipamezole is generally administered 15-60 minutes after medetomidine or dexmedetomidine injection.
Dogs: The dose of atipamezole hydrochloride (in µg per kg of bodyweight) is five times that of the previous dose of medetomidine hydrochloride or ten times that of the dose of dexmedetomidine hydrochloride. Due to the fivefold concentration of the active ingredient (atipamezole hydrochloride) in this product compared to that of preparations containing 1 mg medetomidine hydrochloride per ml and the tenfold concentration compared to that of preparations containing 0.5 mg dexmedetomidine hydrochloride, an equal volume of each preparation is required.
Due to the 50-fold concentration compared to that preparations containing 0.1 mg dexmedetomidine hydrochloride, a volume 5 times lower of the atipamezole preparation is required.
Dosage example dogs:
|
Medetomidine 1.0 mg/ml solution for injection dosage |
Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage |
|
0.04 ml/kg body weight (bw), corresponding with 40 μg/kg bw |
0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw |
|
Dexmedetomidine 0.5 mg/ml solution for injection dosage |
Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage |
|
0.04 ml/kg body weight (bw), corresponding with 20 μg/kg bw |
0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw |
|
Dexmedetomidine 0.1 mg/ml solution for injection dosage |
Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage |
|
0.2 ml/kg body weight (bw), corresponding with 20 μg/kg bw |
0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw |
Cats: The atipamezole hydrochloride dose (in µg per kg of bodyweight) is 2.5 times that of the previous dose of medetomidine hydrochloride or five times that of the dose of dexmedetomidine hydrochloride. Due to the fivefold concentration of the active ingredient (atipamezole hydrochloride) in this product compared to that of preparations containing 1 mg medetomidine hydrochloride per ml and the tenfold concentration compared to that of preparations containing 0.5 mg dexmedetomidine hydrochloride, half the volume of the product to that of the previously administered medetomidine or dexmedetomidine should be given.
Due to the 50-fold concentration compared to that preparations containing 0.1 mg dexmedetomidine hydrochloride, a volume 10 times lower of the atipamezole preparation is required.
Dosage example cats:
|
Medetomidine 1.0 mg/ml solution for injection dosage |
Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage |
|
0.08 ml/kg body weight (bw), corresponding with 80 μg/kg bw |
0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw |
|
Dexmedetomidine 0.5 mg/ml solution for injection dosage |
Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage |
|
0.08 ml/kg body weight (bw), corresponding with 40 μg/kg bw |
0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw |
|
Dexmedetomidine 0.1 mg/ml solution for injection dosage |
Atipamezole hydrochloride 5.0 mg/ml solution for injection dosage |
|
0.4 ml/kg body weight (bw), corresponding with 40 μg/kg bw |
0.04 ml/kg body weight (bw), corresponding with 200 μg/kg bw |
The recovery time for dogs and cats is shortened to approximately 5 minutes. The animals become mobile after approximately 10 minutes after administration of the product.
Adverse reactions
A transient hypotensive effect has been observed during the first 10 minutes after the injection of atipamezole hydrochloride. In rare cases hyperactivity, tachycardia, salivation, atypical vocalisation, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination and uncontrolled defecation may occur. In very rare cases recurrence of sedation may occur or the recovery time may not be shortened after administration of atipamezole.
In cats, when using a low dose to partially reverse the effects of medetomidine or dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be kept in mind.
The frequency of adverse reactions is defined using the following convention:
- Very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment).
- Common (more than 1 but less than 10 animals in 100 animals).
- Uncommon (more than 1 but less than 10 animals in 1,000 animals).
- Rare (more than 1 but less than 10 animals in 10,000 animals).
- Very rare (less than 1 animal in 10,000 animals, including isolated reports).
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