Dorbene vet.
Active substance
ATC code
Species
Dogs and cats.
Indications
In dogs and cats:
Sedation to facilitate handling. Premedication prior to general anaesthesia.
In cats:
In combination with ketamine for general anaesthesia for minor surgical procedures of short duration.
Dose to be administered and administration route
Dorbene vet 1 mg/ml is intended for:
Dogs: Intramuscular or intravenous injection.
Cats: Intramuscular and subcutaneous injection.
Use of an appropriately graduated syringe is recommended to ensure accurate dosing when administering small volumes.
Dogs:
For sedation Dorbene vet 1 mg/ml should be administered at the rate of 750 µg medetomidine hydrochloride i.v. or 1000 µg medetomidine hydrochloride i.m. per square meter of body surface, corresponding to dose of 20-80 µg medetomidine hydrochloride per kg body weight.
Use the table below to determine the correct dosage on the basis of body weight: Maximal effect is obtained within 15-20 minutes. Clinical effect is dose-dependent, lasting from 30 – 180 minutes.
Dorbene vet 1 mg/ml dosages for sedation in ml and corresponding amount of medetomidine hydrochloride in μg /kg bw. For pre-medication use 50% of the dose indicated in the table:
|
body weight (kg) |
intravenous injection (ml) |
corresponding to (μg/kg bw) |
Intramuscular injection (ml) |
corresponding to (μg/kg bw) |
|
1 |
0.08 |
80.0 |
0.10 |
100.0 |
|
2 |
0.12 |
60.0 |
0.16 |
80.0 |
|
3 |
0.16 |
53.3 |
0.21 |
70.0 |
|
4 |
0.19 |
47.5 |
0.25 |
62.5 |
|
5 |
0.22 |
44.0 |
0.30 |
60.0 |
|
6 |
0.25 |
41.7 |
0.33 |
55.0 |
|
7 |
0.28 |
40.0 |
0.37 |
52.9 |
|
8 |
0.30 |
37.5 |
0.40 |
50.0 |
|
9 |
0.33 |
36.7 |
0.44 |
48.9 |
|
10 |
0.35 |
35.0 |
0.47 |
47.0 |
|
12 |
0.40 |
33.3 |
0.53 |
44.2 |
|
14 |
0.44 |
31.4 |
0.59 |
42.1 |
|
16 |
0.48 |
30.0 |
0.64 |
40.0 |
|
18 |
0.52 |
28.9 |
0.69 |
38.3 |
|
20 |
0.56 |
28.0 |
0.74 |
37.0 |
|
25 |
0.65 |
26.0 |
0.86 |
34.4 |
|
30 |
0.73 |
24.3 |
0.98 |
32.7 |
|
35 |
0.81 |
23.1 |
1.08 |
30.9 |
|
40 |
0.89 |
22.2 |
1.18 |
29.5 |
|
50 |
1.03 |
20.6 |
1.37 |
27.4 |
|
60 |
1.16 |
19.3 |
1.55 |
25.8 |
|
70 |
1.29 |
18.4 |
1.72 |
24.6 |
|
80 |
1.41 |
17.6 |
1.88 |
23.5 |
|
90 |
1.52 |
16.9 |
2.03 |
22.6 |
|
100 |
1.63 |
16.3 |
2,18 |
21.8 |
For premedication Dorbene vet 1 mg/ml should be administered at a dosage of 10-40 µg medetomidine hydrochloride per kg body weight, corresponding to 0.1-0.4 ml Dorbene vet 1 mg/ml per 10 kg body weight. The exact dose depends on the combination of drugs used and the dosage(s) of the other drug(s). The dose should furthermore be adjusted to the type of surgery, length of procedure and patient temperament and weight. Premedication with medetomidine will significantly reduce the dosage of the induction agent required and will reduce volatile anaesthetic requirements for maintenance anaesthesia. All anaesthetic agents used for induction or maintenance of anaesthesia should be administered to effect. Before using any combinations, product literature for the other products should be observed. See also section 4.5.
Cats:
For moderate-deep sedation and restraint of cats Dorbene vet 1 mg/ml should be administered at a dosage of 50 – 150 µg medetomidine hydrochloride /kg bw (corresp. to 0.05 – 0.15 ml Dorbene vet 1 mg/ml / kg bw). The speed of induction is slower when subcutaneous route of administration is used.
For anaesthesia Dorbene vet 1 mg/ml should be administered at a dosage of 80 µg medetomidine hydrochloride / kg bw (corresp. to 0.08 ml Dorbene vet 1 mg/ml / kg bw) and 2.5 to 7.5 mg ketamine / kg bw. Using this dosage anaesthesia occurs within 3 – 4 minutes and is apparent for 20 – 50 minutes. For longer lasting procedures administration has to be repeated by using ½ of the initial dose (i.e. 40 µg medetomidine hydrochloride (corresp. to 0.04 ml Dorbene / kg bw) and 2.5 - 3.75 mg ketamine / kg bw) or 3.0 mg ketamine / kg bw alone. Alternatively, for longer lasting procedures anaesthesia may be extended by use of the inhalation agents isoflurane or halothane, with oxygen or oxygen/nitrous oxide. See section 4.5
Adverse reactions
A decrease in heart rate and rate of respiration should be expected following administration. Bradycardia with atrioventricular block (1st and 2nd degree) and occasionally extrasystolia. Vasoconstriction of coronary artery. Decreased cardiac output. Blood pressure will increase initially after administration and then return to normal, or slightly below normal.
The product may have an emetic effect, particularly in cats. This occurs within a few minutes of administration. Cats may also vomit on recovery. Hypersensitivity to loud noise may also occur.
Increased diuresis, hypothermia, respiratory depression, cyanosis, pain at injection site and muscle tremor may be seen. In individual cases reversible hyperglycaemia due to depression of insulin secretion has been observed. Pulmonary oedema has been reported as a rare adverse reaction after use of medetomidine. In circulatory and respiratory depression manual ventilation and an oxygen supplement may be indicated. Atropine may increase the cardiac rate.
Dogs with a body weight of less than 10 kg may show the undesirable effects mentioned above more often.
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