Halofusol
Active substance
ATC code
Species
Cattle (newborn calves).
Indications
In new born calves:
•Prevention of diarrhoea due to diagnosed Cryptosporidium parvum in farms with history of cryptosporidiosis.
Administration should start in the first 24 to 48 hours of life.
•Reduction of diarrhoea due to diagnosed Cryptosporidium parvum.
Administration should start within 24 hours after the onset of diarrhoea.
In both cases, the reduction of oocysts excretion has been demonstrated.
Dose to be administered and administration route
For oral use in calves after feeding.
The dosage is: 100 µg of halofuginone base / kg bw / once a day for 7 consecutive days, i.e. 4 ml of the product / 20 kg bw / once a day for 7 consecutive days.
However, in order to make the product treatment easier, a simplified dosage scheme is proposed:
• 35 kg < calves ≤ 45 kg: 8 ml of the product once a day during 7 consecutive days
• 45 kg < calves < 60 kg: 12 ml of the product once a day during 7 consecutive days
For smaller or higher weights, a precise calculation should be performed (4 ml/20 kg). To ensure a correct dosage, the use of either the metering pump included or any appropriate device for oral administration is necessary. In case of using the metering pump included, it should not be used upside down, and has to be proceed as follows:
1) Screw the metering pump on the bottle.
2) Remove the protector cap from the nozzle.
3) If the metering pump is used for the first time (or hasn’t been used for a few days), carefully pump till a drop of solution is formed on top of the nozzle.
4) Restrain the calf and insert the nozzle of the metering pump into the calves mouth.
5) Pull the trigger of the metering pump completely for release of a dose that equals 4 ml of solution. Pull twice or three times, respectively, for administration of the desired volume (8 ml for calves of 35 – 45 kg and 12 ml for calves of 45 – 60 kg, respectively).
6) Unscrew the metering pump on the bottle.
7) Close the bottle with the screw cap.
8) Pull twice or three times in order to empty the remained product in the metering pump.
9) Put the protector cap back on the nozzle.
The consecutive treatment should be done at the same time each day.
Once the first calf has been treated, all the forthcoming new-born calves must be systematically treated as long as the risk for diarrhoea due to C. parvum persists.
Adverse reactions
In very rare cases, an increase in the level of diarrhoea has been observed in treated animals.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
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