Revertor vet.

1 x 10 ml

Liquid for injection, solution

Active substance

Atipamezol (Atipamezole hydrochloride) : 5 mg/ml

ATC code

QV03AB90 Atipamezole

QV03AB Antidotes

QV03A All other therapeutic products

QV03 All other therapeutic products

QV Various

Species

Dogs and Cats.

Indications

Atipamezole hydrochloride is a selective α2-Antagonist and indicated for reversal of the sedative effects of medetomidine and dexmedetomidine in dogs and cats.

Dose to be administered and administration route

For single intramuscular injection.

Atipamezole hydrochloride is administered 15-60 min after medetomidine or dexmedetomidine hydrochloride administration.

Dogs: the intramuscular atipamezole hydrochloride dose [in µg] is five times that of the previous medetomidine hydrochloride dose or ten times that of the dexmedetomidine hydrochloride dose. Due to the 5-fold higher concentration of the active ingredient (atipamezole hydrochloride) in this product compared to that of preparations containing 1 mg medetomidine hydrochloride per ml and the 10-fold higher concentration compared to that of preparations containing 0.5 mg dexmedetomidine hydrochloride, an equal volume of each preparation is required.

Dosage example Dogs:

Medetomidine 1 mg/ml solution for injection dosage	Revertor 5 mg/ml solution for injection for dogs dosage
0,04 ml/kg body weight (bw), i.e. 40 µg/kg bw	0,04 ml/kg bw, i.e. 200 µg/kg bw
Dexmedetomidine 0.5 mg/ml solution for injection dosage	Revertor 5 mg/ml solution for injection for dogs dosage
0,04 ml/kg body weight (bw), i.e. 20 µg/kg bw	0,04 ml/kg bw, i.e. 200 µg/kg bw

Cats: the intramuscular atipamezole hydrochloride dose [in µg] is two-and-a-half times that of the previous medetomidine hydrochloride dose or five times that of the dexmedetomidine hydrochloride dose. Due to the 5-fold higher concentration of the active ingredient (atipamezole hydrochloride) in this product compared to that of preparations containing 1 mg medetomidine hydrochloride per ml and the 10-fold higher concentration compared to that of preparations containing 0.5 mg dexmedetomidine hydrochloride, half the volume of the product to that of the previously administered medetomidine or dexmedetomidine should be given.

Dosage example Cats:

Medetomidine 1 mg/ml solution for injection dosage	Revertor 5 mg/ml solution for injection for cats dosage
0,08 ml/kg body weight (bw), i.e. 80 µg/kg bw	0,04 ml/kg bw, i.e. 200 µg/kg bw
Dexmedetomidine 0.5 mg/ml solution for injection dosage	Revertor 5 mg/ml solution for injection for cats dosage
0,08 ml/kg body weight (bw), i.e. 40 µg/kg bw	0,04 ml/kg bw, i.e. 200 µg/kg bw

The recovery time is shortened to approximately 5 minutes. The animal becomes mobile after approximately 10 minutes after administration of the product.

Adverse reactions

A transient hypotensive effect has been observed during the first 10 minutes postinjection of atipamezole hydrochloride. In rare cases hyperactivity, tachycardia, salivation, atypical vocalisation, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination and uncontrolled defecation may occur. In very rare cases recurrence of sedation may occur or the recovery time may not be shortened after administration of atipamezole.

In cats, when using low doses to partially reverse the effects of medetomidine or dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be guarded against.