Medesedan
Active substance
ATC code
Species
Horse, cattle.
Indications
For the sedation and slight analgesia of horses and cattle, to facilitate physical examinations and treatments, such as minor surgical interventions.
Detomidine can be used for:
• Examinations (e.g. endoscopy, rectal and gynaecological examinations, X-rays).
• Minor surgical procedures (e.g. treatment of wounds, dental treatment, tendon treatment, excision of skin tumours, teat treatment).
• Before treatment and medication (e.g. stomach tube, horse shoeing).
For premedication prior to administration of injection- or inhalation anaesthetics.
See section 4.5 before use.
Dose to be administered and administration route
For intravenous (IV) or intramuscular (IM) use. The product should be injected slowly. Onset of effect is more rapid following intravenous use.
|
Dosage in mcg/kg |
Dosage in ml/100 kg |
Level of sedation |
Commencement of effect (min) |
Duration of effect (hrs) |
|
|
horse |
cattle |
||||
|
10-20 |
0.1-0.2 |
Light |
3-5 |
5-8 |
0.5-1 |
|
20-40 |
0.2-0.4 |
Moderate |
3-5 |
5-8 |
0.5-1 |
When prolonged sedation and analgesia is required, doses of 40 to 80 µg/kg can be used. The duration of effect is up to 3 hours.
For combination with other product to intensify the sedation or for premedication prior to general anaesthesia, doses of 10 to 30 µg/kg can be used.
It is recommended to wait 15 minutes after the detomidine administration before starting the planned procedure.
The bodyweight of the animal to be treated should be determined as accurately as possible to avoid overdosing.
Adverse reactions
Injection of detomidine may cause the following side effects:
• Bradycardia
• Transient hypo- and/or hypertension.
• Respiratory depression, rarely hyperventilation,
• Increase in blood glucose
• As with other sedatives, in rare cases paradoxical reactions (excitations) can develop.
• Ataxia
• Uterine contractions
• In horses: Cardiac arrhythmia, atrioventricular and sino-atrial block
• In cattle: Inhibition of rumen motility, tympania, paralysis of the tongue.
At doses above 40 µg/kg bodyweight, the following symptoms can also be observed: sweating, pilo-erection and tremor of muscles, transient penis prolaps in stallions and geldings and mild, transient tympania of rumen and increased salivation in cattle.
In very rare cases horses may show mild symptoms of colic following administration of alpha-2 sympathomimetics because substances of this class transiently inhibit the motility of the intestines. Detomidine should be prescribed with caution in horses which present with signs of colic or impaction.
A diuretic effect is usually observed within 45 to 60 minutes after treatment.
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|---|---|
| Art. Nr. | 20916/4002 |
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