Evanovo
Active substance
ATC code
Species
Chicken embryonated eggs.
Indications
For the active immunisation of chickens to reduce clinical signs, intestinal lesions and oocysts output associated with coccidiosis caused by Eimeria acervulina, Eimeria maxima, Eimeria praecox and Eimeria tenella.
Onset of immunity: 21 days of age.
Duration of immunity: 63 days of age in an environment that permits oocysts recycling.
Dose to be administered and administration route
In ovo administration.
Vaccination schedule:
Administer one single injection of 0.05 ml or 0.1 ml of the diluted vaccine suspension into each chicken egg at 18 days of embryonation.
Method of administration:
An automated egg injection machine can be used. In ovo equipment should be previously calibrated to ensure that a 0.05 ml or 0.1 ml dose is applied. The instructions for the calibration and use of the equipment should be strictly followed, in order to deliver the appropriate dose in the amnion of the embryonated egg.
For the dilution and administration of the vaccine, use sterile equipment free from any residues of chemical disinfectants.
Prepare the required volume of the vaccine as per the examples provided in the tables below, showing different dilution possibilities, according to different presentations:
Dilutions for in ovo administration (0.05 ml per dose):
Number and content of vaccine vials | HIPRAHATCH solvent, for poultry vaccines volume to be used | Volume of solvent to be withdrawn before vaccine dilution |
4 x 1,000 doses | 200 ml | 24 ml |
2 x 2,000 doses | 200 ml | 24 ml |
4 x 2,000 doses | 400 ml | 48 ml |
1 x 4,000 doses | 200 ml | 24 ml |
2 x 4,000 doses | 400 ml | 48 ml |
4 x 4,000 doses | 800 ml | 96 ml |
5 x 4,000 doses | 1,000 ml | 120 ml |
2 x 5,000 doses | 500 ml | 60 ml |
4 x 5,000 doses | 1,000 ml | 120 ml |
1 x 8,000 doses | 400 ml | 48 ml |
2 x 8,000 doses | 800 ml | 96 ml |
1 x 10,000 doses | 500 ml | 60 ml |
2 x 10,000 doses | 1,000 ml | 120 ml |
Dilutions for in ovo administration (0.1 ml per dose):
Number and content of vaccine vials | HIPRAHATCH solvent, for poultry vaccines volume to be used | Volume of solvent to be withdrawn before vaccine dilution |
2 x 1,000 doses | 200 ml | 12 ml |
4 x 1,000 doses | 400 ml | 24 ml |
1 x 2,000 doses | 200 ml | 12 ml |
2 x 2,000 doses | 400 ml | 24 ml |
4 x 2,000 doses | 800 ml | 48 ml |
1 x 4,000 doses | 400 ml | 24 ml |
2 x 4,000 doses | 800 ml | 48 ml |
1 x 5,000 doses | 500 ml | 30 ml |
2 x 5,000 doses | 1,000 ml | 60 ml |
1 x 8,000 doses | 800 ml | 48 ml |
1 x 10,000 doses | 1,000 ml | 60 ml |
Dilution of the vaccine:
1. Withdraw from the HIPRAHATCH solvent, for poultry vaccines bag the same millilitres that are going to be injected of vaccine (EVANOVO), as stated in the example tables above.
2. Shake the vaccine vial/s and inject the content of it/them into the HIPRAHATCH solvent, for poultry vaccines bag.
Mix the contents of the bag by gentle agitation until the contents are completely diluted.
3. The diluted vaccine is a white suspension, which should be used within 10 hours after dilution. Mix the bag by gentle agitation every 30 minutes during vaccination.
The vaccine must be injected into the amniotic sac of 18-day-old embryonated chicken eggs.
For simultaneous use with GUMBOHATCH, the mixed administration of EVANOVO and GUMBOHATCH should only be used when vaccinating in ovo 18-day-old embryonated eggs.
The following instructions should be used:
1.1 Taking into account the HIPRAHATCH solvent, for poultry vaccines bag volume, prepare the EVANOVO vaccine as described above.
1.2 Once the EVANOVO vaccine has been prepared, consider the bag volume to prepare enough GUMBOHATCH doses for the bag volume.
1.3 In each GUMBOHATCH vial to be used, insert 4 ml of the EVANOVO diluted vaccinal suspension prepared in section 1.1.
1.4 Once the lyophilized tablet is properly resuspended, introduce the volumes of the different GUMBOHATCH vials into the vaccinal bag.
1.5 Homogenize by moving the bag volume with the hands until having an even homogenate solution.
1.6 Vaccinate using the vaccinal bag with the mixed vaccines within a period of 2 hours via in ovo. Mix the bag by gentle agitation every 30 minutes during vaccination.
Prepare the required volume of each vaccine as per the examples provided in the table below, showing different mixing possibilities, according to different presentations for in ovo administration (0.05 ml per dose):
GUMBOHATCH (Number and content of vaccine vials) | EVANOVO (Number and content of vaccine vials) | HIPRAHATCH solvent, for poultry vaccines volume to be used |
4 x 1,000 doses | 4 x 1,000 doses | 200 ml |
2 x 2,000 doses | 2 x 2,000 doses | 200 ml |
4 x 2,000 doses | 4 x 2,000 doses | 400 ml |
1 x 4,000 doses | 1 x 4,000 doses | 200 ml |
2 x 4,000 doses | 4 x 2,000 doses | 400 ml |
2 x 4,000 doses | 2 x 4,000 doses | 400 ml |
4 x 4,000 doses | 4 x 4,000 doses | 800 ml |
2 x 5,000 doses | 2 x 5,000 doses | 500 ml |
8 x 2,500 doses | 4 x 5,000 doses | 1,000 ml |
2 x 4,000 doses | 1 x 8,000 doses | 400 ml |
4 x 4,000 doses | 2 x 8,000 doses | 800 ml |
4 x 2,500 doses | 1 x 10,000 doses | 500 ml |
5 x 4,000 doses | 2 x 10,000 doses | 1,000 ml |
4 x 5,000 doses | 2 x 10,000 doses | 1,000 ml |
The vaccine should not be used in case its appearance is different from a white turbid suspension.
Adverse reactions
None known.
