Suiseng Diff/A
Active substance
ATC code
Species
Pigs (pregnant sows and gilts).
Indications
For the passive immunisation of neonatal piglets by means of the active immunisation of breeding sows and gilts:
- to prevent mortality and reduce clinical signs and macroscopic lesions caused by C. difficile, toxins A and B.
- to reduce clinical signs and macroscopic lesions caused by C. perfringens type A, α-toxin.
The reduction of the occurrence of neonatal diarrhoea has been demonstrated under field conditions.
Onset of immunity:
Protection was demonstrated in suckling piglets on the first day of life in challenge studies.
Duration of immunity:
Neutralising protective antibodies transferred via colostrum to the piglets were present up to 28 days after birth in the majority of the piglets.
Dose to be administered and administration route
Administer the vaccine by deep intramuscular injection in the neck muscles.
Allow the vaccine to reach room temperature (15°C to 25 °C) before use. Shake well before use.
Primary vaccination:
Administer one dose (2 ml) at approximately 6 weeks before farrowing and a second dose (2 ml) at approximately 3 weeks before farrowing.
It is recommended that the second dose is given preferably on alternate sides.
Revaccination:
On each subsequent gestation, administer one dose (2ml) 3 weeks before the expected date of farrowing.
Adverse reactions
Mild local inflammation at the injection site (maximum diameter of 5 cm) which subsided without treatment within 5 days was commonly reported in laboratory studies.
A slight transient increase in body temperature (mean 0.27ºC, in individual pigs up to 0.95 ºC) which subsided without treatment occurred commonly in preclinical and field studies.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reactions
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
