Hipragumboro CW
ATC code
Species
Chickens.
Indications
For active immunisation of chicken (broilers) with maternally derived antibodies (MDA ELISA breakthrough titre of 115) to prevent clinical signs and to reduce loss of weight and bursal damage caused by Gumboro Disease.
The onset of immunity is 14 days post vaccination.
The duration of immunity: 30 days post vaccination.
Dose to be administered and administration route
Administer one dose of the vaccine per chicken in the drinking water.
Most of the commercial chicks are hatched with maternal antibodies which might neutralize the vaccine. Due to this fact it is required to calculate the proper vaccination time. The optimum age for vaccination is calculated, after testing the level of maternal antibodies of 18-20 chicks of the flock, by means of the Deventer Formula.
According to this formula the optimum age of vaccination is as follows:
IBD antibody ELISA titre of bird(%):
ELISA titre of the bird (at sampling) representing a certain percentage of the flock that is desired to be susceptible to the vaccine at the time of the application
Breakthrough titre of the vaccine:
ELISA titre that the vaccine is able to breakthrough t0.5:
Half-life time of the antibodies (ELISA titre) in the type of chickens being sampled
Age at sampling:
Age of the birds at sampling
Correction 0-4:
Extra days when the sampling was done at 0 to 4 days of age.
Reconstitution of the vaccine:
Open the vaccine vial and introduce 10 ml of drinking water without chlorine or disinfectants. Shake gently until the complete reconstitution of the freeze-dried powder is achieved.
Other alternative is to open the vial under the water. The empty vial should be rinsed a couple of times to ensure the complete reconstitution of the vaccine.
Method of administration:
It is important to use clean cold water, free from chlorine and other disinfectants. The volume of water for reconstitution of the vaccine depends on the daily water consumption which is related with the age of the birds, the environment temperature and the management practices.
The volume of water should be adjusted to ensure that the vaccine solution is consumed in 1 hour up to 2 hours the maximum.
If the birds have higher or lower water consumption times, adjust the volume accordingly to ensure the proper water consumption time.
The following management practices should improve the vaccine intake:
Water should be withheld for 1-2 hours prior vaccination to increase the thirst of the birds and ensure that all reconstituted vaccine is consumed within 1 to 2 hours.
Bell drinker vaccination: it is recommended to empty and clean the bell drinkers during the water withholding period. When the water restriction period is finished the vaccine is reconstituted as indicated previously and it is delivered to the birds.
Nipple drinker vaccination: a considerable amount of residual water might remain in the lines after the water withholding period. It is recommended to drain the lines and load them with the vaccine solution before allowing the birds to have access to the nipples.
Always ensure that the feed is available when vaccinating. The birds will not drink enough if they do not have access to feed.
Adverse reactions
In very rare cases notable transient lymphocyte depletion can be observed in birds on day 7 post-vaccination. The repopulation of the follicles by lymphocytes starts after day 7 post-vaccination, being specially evident on 21 days postvaccination. By day 28 post-vaccination only mild lesions remain in some birds. This does not result in an immune-supressive effect.
The frequency of adverse reactions is defined using the following convention: Very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment).
-Common (more than 1 but less than 10 animals in 100 animals).
Uncommon (more than 1 but less than 10 animals in 1,000 animals).
Rare (more than 1 but less than 10 animals in 10,000 animals).
Very rare (less than 1 animal in 10,000 animals, including isolated reports).
