Fentadon vet.
Active substance
ATC code
Species
Dogs.
Indications
For intra-operative analgesia during surgical procedures such as soft tissue and orthopaedic surgery.
For the control of post-operative pain associated with major orthopaedic and soft tissue surgery.
Dose to be administered and administration route
For intravenous administration. The weight of the animal to be treated should be accurately determined before the administration of the product. Onset of action is seen within 5 minutes. The duration of the analgesic effect is 20 (lowest recommended dose) to 40 minutes (highest recommended dose).
Fentanyl can be administered according to the following dosage regimen:
Analgesia by Continuous Rate Infusion (CRI)
• 5 - 10 µg/kg (0.1 - 0.2 ml/kg) IV as a bolus, followed by 12 - 24 µg/kg/hr (0.24 - 0.48 ml/kg/hr) IV for intra-operative analgesia as CRI.
• 6 - 10 µg/kg/hr (0.12 - 0.2 ml/kg/hr) IV for subsequent post-operative analgesia as CRI in sedated animals. During post-operative CRI administration of fentanyl, animals should be monitored carefully.
Chemical-physical compatibility has only been demonstrated for dilutions 1:5 with the following solutions for infusion: sodium chloride 0.9%, Ringer’s solution and glucose 5%.
The veterinary medicinal product has a narrow margin of safety and it is important to measure the dose accurately to avoid overdosing.
Adverse reactions
In analogy with other narcotic analgesics, common serious adverse reactions with fentanyl are respiratory depression and bradycardia. Bradycardia may occur due to increased cardiac vagal stimulation. The respiratory depressant effects can be of long duration and may exhibit a biphasic pattern.
Also common is a transient fall in blood pressure following intravenous administration of fentanyl citrate injection even at doses of 2.5 - 5 μg/kg. Hypothermia may occur. Lowered nociceptive thresholds in dogs when the effects of the drug dissipate have been described.
The following adverse reactions have been observed during studies with the product and occur very commonly:
Rapid breathing, panting, urination, defecation, vocalization, tongue protrusion, overactivity, irritability, body tremors, vomiting, scratching and sedation.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reaction(s) during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10.000 animals, including isolated reports)
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| Art. Nr. | 16849/5014 |
| EAN | 8714225154784 |
