Fentadon vet.

1 x 10 ml

Liquid for injection, solution

Active substance

Fentanyl (Fentanyl citrate) : 50 mikg/ml

ATC code

QN02AB03 Fentanyl

QN02AB Phenylpiperidine derivatives

QN02A Opioids

QN02 Analgesics

QN Nervous system

Species

Dogs.

Indications

For intra-operative analgesia during surgical procedures such as soft tissue and orthopaedic surgery.

For the control of post-operative pain associated with major orthopaedic and soft tissue surgery.

Dose to be administered and administration route

For intravenous use.

To ensure a correct dosage, body weight should be determined as accurately as possible. Onset of action is seen within 5 minutes. The duration of the analgesic effect is 20 (lowest recommended dose) to 40 minutes (highest recommended dose).

Fentanyl can be administered according to the following dosage regimen:

Analgesia by Continuous Rate Infusion (CRI)

• 5 – 10 µg/kg (0.1 - 0.2 ml/kg) IV as a bolus, followed by 12 – 24 µg/kg/hr (0.24 - 0.48 ml/kg/hr) IV for intra-operative analgesia as CRI.

• 6 – 10 µg/kg/hr (0.12 - 0.2 ml/kg/hr) IV for subsequent post-operative analgesia as CRI in sedated animals. During post-operative CRI administration of fentanyl, animals should be monitored carefully.

Chemical-physical compatibility has only been demonstrated for dilutions 1:5 with the following solutions for infusion: sodium chloride 0.9%, Ringer’s solution and glucose

5%.

The veterinary medicinal product has a narrow margin of safety and it is important to measure the dose accurately to avoid overdosing.

Adverse reactions

Dogs:

Very common

(>1 animal / 10 animals treated):

Hyperactivity, Irritability, Vocalisation

Involuntary defecation, Tongue protrusion,

Vomiting

Tremor ^a, Sedation

Urination

Increased respiratory rate, Panting

Scratching

Common

(1 to 10 animals / 100 animals treated):

Respiratory depression ^b

Bradycardia ^c, Hypotension ^d

Uncommon

(1 to 10 animals / 1,000 animals treated):

Hypothermia

Rare

(1 to 10 animals / 10,000 animals treated):

Lowered nociceptive thresholds ^e

a Tremors of the body. b Can be of long duration and may exhibit a biphasic pattern. c Due to increased cardiac vagal stimulation.

d Transient. Following intravenous administration of fentanyl citrate even at doses of 2.5 – 5 μg/kg. e When the effects of the drug dissipate.

Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.