Ovarelin

Intramuscular use.

100 µg of gonadorelin (as diacetate) per animal in a single injection. i.e. 2 ml of the product per animal.

Judgement on the protocol to be used should be made by the veterinarian responsible for treatment, on the basis of the treatment objectives of the individual herd or cow. The following protocols have been evaluated and could be used:

Induction and synchronisation of oestrus and ovulation in combination with a prostaglandin F2α (PGF2α) or analogue:

• Day 0: First injection of gonadorelin (2 ml of the product)

• Day 7: Injection of prostaglandin (PGF2 α) or analogue

• Day 9: Second injection of gonadorelin (2 ml of the product) should be done.

The animal should be inseminated within 16-20 hours after the last injection of the product or at observed oestrus if sooner.

Induction and synchronisation of oestrus and ovulation in combination with a prostaglandin F2α (PGF2α) or analogue and a progesterone releasing intravaginal device:

The following FTAI protocols have been commonly reported in the literature:

• Insert progesterone releasing intravaginal device for 7 days.

• Inject gonadorelin (2 ml of the product) at the progesterone device insertion.

• Inject a prostaglandin (PGF2 α) or analogue 24 hours prior to device removal

• FTAI 56 hours after removal of the device, or

• Inject gonadorelin (2 ml of the product) 36 hours after progesterone releasing intravaginal device removal and FTAI 16 to 20 hours later.

Treatment of delayed ovulation (repeat-breeding):

GnRH is injected during oestrus.

To improve the pregnancy rates, the following timing of injection and insemination should be followed:

- injection should be performed between 4 and 10 hours after oestrus detection

- an interval of at least 2 hours between the injection of GnRH and artificial insemination is recommended.

- artificial insemination should be carried out in accordance with the usual field recommendations, i.e., 12 to 24 hours after oestrus detection.