Novamune
Active substance
ATC code
Species
Chickens
Indications
For active immunisation of day-old future layer chickens in order to reduce clinical signs and acute lesions of bursa of Fabricius caused by very virulent Avian Infectious Bursal Disease (IBD) virus infection.
Onset of immunity is expected from 30 days depending on the initial MDA level.
The immunisation is influenced by the natural decline of maternally derived antibodies (MDA), and has been found to occur when MDA have reached appropriate release level. The onset of clinical protection depends on the initial MDA level. In vaccinated day old future layer chicks the release of the vaccine virus (vaccine virus take) was observed between 21-42 days after vaccination.
Duration of immunity: 9 weeks.
The virulent challenge tests conducted to support the claim were carried out on day old future layer chicks having MDA ELISA titre of 3,000 to 5,700 (average Day 0 MDA levels).
Field trials carried out showed that vaccine virus replication in the bursa of Fabricius occurs in day old future layer chicks having average MDA titre levels of 6,000 ELISA units.
Dose to be administered and administration route
The vaccine must be administered by subcutaneous route
The vaccine is to be administered once at 1 day of age. Automatic syringe may be used. The injection volume is 0.2 ml per dose. The vaccine is delivered under the skin of the neck.
Use sterile devices and equipment for reconstitution and for administration of the vaccine.
Proposed dilutions for subcutaneous administration:
|
Number of vaccine ampoules |
Solvent |
Volume of one dose |
|
2 x 500 doses |
200 ml |
0.2 ml |
|
4 x 500 doses |
400 ml |
|
|
8 x 500 doses |
800 ml |
|
|
1 x 1000 doses |
200 ml |
|
|
2 x 1000 doses |
400 ml |
|
|
4 x 1000 doses |
800 ml |
|
|
1 x 2000 doses |
400 ml |
|
|
2 x 2000 doses |
800 ml |
|
|
2 x 2000 + 1 x 1000 doses |
1000 ml |
|
|
3 x 2000 doses |
1200ml |
|
|
4 x 2000 doses |
1600 ml |
Preparation of vaccine:
1. After matching the dose size of the vaccine ampoule(s) with the solvent size, quickly remove from liquid nitrogen container the exact number of ampoules needed.
2. Draw up 2-5 ml of solvent into a 5-10 ml sterile syringe. Use at least 18 gauge needles.
3. Thaw rapidly the contents of the ampoules by gentle agitation in water at 27-39°C.
4. As soon as they are completely thawed, open ampoules holding them at arm’s length in order to prevent any risk of injury should the ampoule break.
5. Once the ampoule is open slowly draw up the content into the needle already containing 25 ml solvent.
6. Transfer the suspension into the solvent bag. The vaccine prepared as described is mixed by gentle agitation.
7. Withdraw a portion of the vaccine into the syringe to rinse ampoule. Remove the washing from the ampoule and inject it gently into the solvent bag. Repeat it one or two times.
8. The vaccine prepared as described is mixed by gentle agitation so as to be ready for use.
Repeat the operations in point 2-7 for the appropriate number of ampoules to be thawed.
Do not use Novamune if you notice visible signs of unacceptable decolourisation in the vials. The reconstituted vaccine is orange to red, clear to opaque suspension. Insoluble particles may be present.
Adverse reactions
In vaccinated chickens, mild to moderate lymphocyte depletion is very common, which is maximal at around 7 days after vaccine take. After 7 days, this depletion decreases and is followed by lymphocyte repopulation and regeneration of the bursa of Fabricius.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports)
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|---|---|
| Art. Nr. | 15052/5032 |
| EAN | 3411113091354 |
