Vectormune ND
Active substance
ATC code
Species
Chickens and embryonated chicken eggs
Indications
For active immunisation of 18-day-old embryonated chicken eggs or one-day-old chicks to reduce mortality and clinical signs caused by Newcastle disease virus and to reduce mortality, clinical signs and lesions caused by virulent Marek’s disease virus.
Onset of immunity against Newcastle disease for broilers and layers: 3 weeks of age.
Duration of immunity against Newcastle disease for broilers: 9 weeks of age.
Duration of immunity against Newcastle disease for layers: 18 weeks of age
Onset of immunity against Marek’s disease for broilers and layers: 1 week of age.
Duration of immunity for broilers and layers: A single vaccination is sufficient to provide protection during the risk period of infection with Marek’s disease virus.
Dose to be administered and administration route
For in-ovo administration and subcutaneous use.
In-ovo administration:
One single dose of 0.05 ml is injected into each 18-day-old embryonated broiler chicken egg. For in-ovo application an automatic in-ovo egg injector can be used. In-ovo equipment should be calibrated to ensure that a 0.05 ml dose is applied to each egg.
Subcutaneous use:
One single injection of 0.2 ml per chick is applied for broilers or layers at one day of age. The vaccine may be injected by an automatic syringe.
Overview table for dilution possibilities of different presentations:
For in-ovo administration:
|
Vaccine ampoule presentation (No. of vaccine ampoules multiplied by doses needed) |
Solvent presentation (ml) |
Volume of one dose (ml) |
|
2 x 2,000 |
200 |
0.05 |
|
1 x 4,000 |
200 |
0.05 |
|
2 x 4,000 |
400 |
0.05 |
|
4 x 4,000 |
800 |
0.05 |
|
5 x 4,000 |
1000 |
0.05 |
|
6 x 4,000 |
1200 |
0.05 |
|
8 x 4,000 |
1600 |
0.05 |
The speed of automatic injection is at least 2,500 eggs per hour, therefore solvent presentation of at least or more than 400 ml is recommended to prime and inject for longer than 10 minutes. In-ovo equipment should be calibrated to ensure that a 0.05 ml dose is applied to each egg.
Solvent presentations smaller than 400 ml are not recommended to be used for in-ovo application by an automated machine as it may not be enough to prime the machine and to inject for longer than 10 minutes. The 200 ml presentation may be used for manual vaccination.
For subcutaneous use:
|
Vaccine ampoule presentation (No. of vaccine ampoules multiplied by doses needed) |
Solvent presentation (ml) |
Volume of one dose (ml) |
|
1 x 1,000 |
200 |
0.20 |
|
1 x 2,000 |
400 |
0.20 |
|
2 x 2,000 |
800 |
0.20 |
|
1 x 4,000 |
800 |
0.20 |
|
4,000 + 1,000 |
1000 |
0.20 |
|
3 x 2,000 |
1200 |
0.20 |
|
2 x 4,000 |
1600 |
0.20 |
The usual aseptic precautions should be applied to all administration procedures. Be familiar with all safety and precautionary measures for handling liquid nitrogen in order to prevent personal injury.
Preparation of vaccine suspension for injection:
1. After matching the dose size of the vaccine ampoule presentation with the solvent bag size, quickly remove the exact number of ampoules needed from the liquid nitrogen container.
2. Draw up 2 ml of solvent into a 5 ml syringe.
3. Thaw rapidly the contents of the ampoules by gentle agitation in water at 27– 39 °C.
4. As soon as they are completely thawed, open ampoules holding them at arm’s length in order to prevent any risk of injury should the ampoule break.
5. Once the ampoule is open, slowly draw up the content into the 5 ml sterile syringe already containing 2 ml of solvent with a needle of at least 18 gauge diameter.
6. Transfer the suspension into the solvent bag. The diluted vaccine prepared as described is mixed by gentle agitation.
7. Withdraw a portion of the diluted vaccine into the syringe to rinse the ampoule.
Remove the washing from the ampoule and inject it gently into the solvent bag. Repeat one or two times.
8. The diluted vaccine prepared as described is mixed by gentle agitation so as to be ready for use.
Repeat the operations in point 2 to 7 for the appropriate number of ampoules to be thawed.
Use the vaccine immediately, slowly mix regularly to ensure uniform suspension of cells and use within a period not exceeding 2 hours.
After adding the content of the ampoule to the solvent, the ready to use product is a clear, red coloured suspension for injection.
Discard any ampoules that have been accidentally thawed.
Do not re-freeze under any circumstances.
Do not re-use opened containers of diluted vaccine.
Adverse reactions
None known.
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|---|---|
| Art. Nr. | 15052/5030 |
| EAN | 3411112958108 |
