Cevaprost

Single or repeated 2ml doses (equivalent to 500 mcg of cloprostenol) by intramuscular injection).

Therapeutic indications:

This condition is particularly common in heavy producing dairy cows, which have normal ovarian cycles but slightly express or do not express behavioural manifestations. These animals can be treated only after checking the cycle activity and the presence of the corpus luteum. Animals treated with the product may be bred (natural service or artificial insemination) 72 and 96 hours after treatment.

If the animal has been treated in the absence of a corpus luteum, another injection of the product is required 11 days after the first injection.

The product has demonstrated its efficacy in restoring normal the oestrus cycle in case of absence of heat caused by ovarian cysts (characterized by the presence of persistent luteal tissue).

The condition may occur in case of immature calves.

The pregnancy can be interrupted starting from one week after its establishment until day 150 of pregnancy. Before day 100, abortion can be induced quickly and effectively while between day 100 and day 150, results may be less significant because some cows may become progressively less sensitive to the action of corpus luteum maintaining pregnancy. The animals must be kept under observation until foetus and placental membranes complete expulsion.

From day 270 of pregnancy, the administration of the product induces parturition 30 – 60 hours of treatment. The induction of parturition should take place as close as possible to the expected date of spontaneous parturition. The induction of parturition should not be induced before day 270 day of pregnancy. All treated animals must be kept under observation. As with all other methods of shortening the pregnancy period, placental retention rate may be increased.

Foetus death may be followed by dehydration and degeneration. The induction of luteolysis at any stage of pregnancy causes the expulsion of mummified foetuses from the uterus to the vagina, from which it is possible to make manual removal. Usually, normal cyclic activity follows.

Reproduction system lesions caused during parturition or placental retention may cause uterine inflammation and infections known as endometritis. Acute or sub-acute endometritis, which may occur shortly after parturition, may require both local and general antibiotic treatments. This condition is known as pyometra and is characterised by the absence of annual cyclic activity and the presence of a persistent corpus luteum. The condition can be successfully treated by inducing the regression of the corpus luteum. If necessary, the treatment may be repeated after 10-14 days.

Controlled breeding:

A treatment consisting of two injections of the product at 11 days interval is highly effective for oestrus synchronization in healthy cycling cows. Two artificial inseminations at 72 and 96 hours after the second injection, involve a normal fertility rate. For economic reasons, if only one insemination is performed, this must be done after 72-84 hours but this may involve fewer pregnancies. Of cause, such protocol can vary. For example, it is possible to inseminate all animals in heat after the first injection and limit the second treatment, to the cows in which the first had no effect.