Nextmune
Active substance
ATC code
Species
Chickens and embryonated chicken eggs (broilers).
Indications
For active immunisation of 18-day-old broiler embryos or day-old broiler chickens in order to reduce clinical signs, virus shedding and acute lesions of the bursa of Fabricius caused by very virulent Avian Infectious Bursal Disease (IBD) virus infection.
In laboratory studies, it was observed that the vaccination with Nextmune can reduce weight loss after infection with vvIBDV as observed 10 days after infection.
Onset of immunity is expected from 21 days of age onwards depending on the initial MDA level.
The immunisation is influenced by the natural decline of maternally derived antibodies (MDA), and has been found to occur when MDA have reached appropriate release level.
Laboratory and field trials have been carried out in birds with MDA titres of 2500-7900 ELISA Units
In vaccinated chicks the release of the vaccine virus (vaccine virus take) was observed between 14-35 days of age in clinical trials.
Duration of immunity: up to 7 weeks of age.
Dose to be administered and administration route
The vaccine can be administered by in ovo or via subcutaneous routes.
Use sterile devices and equipment for reconstitution and for administration of the vaccine.
Match the dose size of the vaccine and the sterile solvent according to the tables below.
In ovo administration
One single dose of 0.05 ml is injected into each 18-day-old embryonated broiler chicken egg using in-ovo equipment. The vaccine is delivered to the amnion sac.
Proposed dilutions for in ovo administration:
|
Number of vaccine ampoules |
Solvent |
Volume of one dose |
|
4 x 2000 doses |
400 ml |
0.05 ml |
|
2 x 4000 doses |
400 ml |
|
|
4 x 4000 doses |
800 ml |
|
|
1 x 8000 doses |
400 ml |
|
|
2 x 8000 doses |
800 ml |
|
|
2 x 8000 + 1x 4000 doses |
1000 ml |
|
|
3 x 8000 doses |
1200 ml |
|
|
4 x 8000 doses |
1600 ml |
Subcutaneous administration
One single injection of 0.2 ml per chick is applied at one day of age. Automatic syringe is recommended to use. The vaccine is delivered under the skin of the neck.
Proposed dilutions for subcutaneous administration:
|
Number of vaccine ampoules |
Solvent |
Volume of one dose |
|
1 x 2000 doses |
400 ml |
0.2 ml |
|
2 x 2000 doses |
800 ml |
|
|
1 x 4000 doses |
800 ml |
|
|
3 x 2000 doses |
1200 ml |
|
|
1 x 8000 doses |
1600 ml |
Preparation of vaccine:
1. After matching the dose size of the vaccine with the solvent (Cevac Solvent Poultry) size, quickly remove from liquid nitrogen container the exact number of ampoules needed.
2. Draw up 2-5 ml of solvent into a 5-10 ml sterile syringe. Use at least 18 gauge needles.
3. Thaw rapidly the contents of the ampoules by gentle agitation in water at 27-39°C.
4. As soon as they are completely thawed, open ampoules holding them at arm’s length in order to prevent any risk of injury should the ampoule break.
5. Once the ampoule is open slowly draw up the content into the needle already containing 2-5 ml solvent.
6. Transfer the suspension into the solvent bag. The diluted vaccine prepared as described is mixed by gentle agitation.
7. Withdraw a portion of the diluted vaccine into the syringe to rinse ampoule. Remove the washing from the ampoule and inject it gently into the solvent bag. Repeat it one or two times.
8. The diluted vaccine prepared as described is mixed by gentle agitation so as to be ready for use.
Repeat the operations in point 2-7 for the appropriate number of ampoules to be thawed.
The reconstituted vaccine is orange to red, clear to opaque suspension. Insoluble particles may be present.
Adverse reactions
In vaccinated chickens, mild to moderate lymphocyte depletion is very common, which is maximal at around 7 days after vaccine take. After further 7 days, this depletion decreases and is followed by lymphocyte repopulation and regeneration of the bursa of Fabricius.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports)
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|---|---|
| Art. Nr. | 15052/4154 |
| EAN | 3411113087111 |
