Cevac Transmune
Active substance
ATC code
Species
Chickens and embryonated chicken eggs.
Indications
For the active immunisation of 18-day-old embryonated broiler hatching eggs or 1-day-old broiler chickens from hens vaccinated against IBD, to reduce mortality, clinical disease, weight loss and acute lesions of bursa of Fabricius associated with infection caused by very virulent Avian Infectious Bursal Disease (IBD) viruses.
The release of the vaccine virus from the complex (and therefore immunisation) is influenced by the natural decline of maternally derived antibodies (MDA), and has been found not to occur until MDA has reached relatively low levels.
The onset of clinical protection depends on the initial MDA level. In vaccinated broilers it is achieved within 1 day after the first signs of vaccine virus effect in the bursa of Fabricius.
Onset of immunity: between 21 and 32 days of age. Duration of immunity: up to 42 days of age.
The virulent challenge tests conducted to support the claim were carried out on broilers having an MDA ELISA titre of 6,000 (1-day-old chicks).
Field trials carried out showed that vaccine virus replication in the bursa of Fabricius occurs in broilers having at hatch MDA titre levels of up to 14,000 ELISA units, but the protection of these birds was evaluated only based on serological data and histology of the bursa of Fabricius.
Dose to be administered and administration route
In-ovo administration
The vaccine is to be administered once at the 18th day of embryonation using in-ovo equipment. The injection volume is 0.05 ml per dose for in-ovo administration. The vaccine is delivered to the amnion sac or, rarely, into the body of the embryo causing no decrease in hatchability.
Use sterile devices and equipment for reconstitution and for administration of the vaccine.
Subcutaneous administration
The vaccine is to be administered once at 1-day of age, automatic syringe may be used. The injection volume is 0.1 ml per dose for subcutaneous administration. The vaccine is delivered under the skin of the neck.
Use sterile devices and equipment for reconstitution and for administration of the vaccine.
Reconstitution of the vaccine
For the reconstitution of Cevac Transmune, PBS, Saline solution or Cevac Solvent Poultry can be used.
In-ovo administration of 0.05 ml per dose:
1. Calculate and prepare the required volume of the reconstituted vaccine as follows:
|
Cevac Transmune |
Solvent |
|
1 x 2,000 doses |
100 ml |
|
1 x 4,000 doses |
200 ml |
|
1 x 5,000 doses |
250 ml |
|
2 x 2,500 doses |
250 ml |
|
2 x 4,000 doses |
400 ml |
|
2 x 5,000 doses |
500 ml |
|
4 x 4,000 doses |
800 ml |
|
4 x 5,000 doses |
1,000 ml |
|
1 x 8,000 doses |
400 ml |
|
6 x 4,000 doses |
1200 ml |
|
8 x 4,000 doses |
1600 ml |
2. Draw up 2 ml of the solvent and transfer into the glass vial containing the lyophilised component.
3. Completely dissolve the vaccine by shaking gently and transfer it into the plastic solvent bottle.
4. Rinse the vial with another 2 ml liquid and transfer the rinsing liquid into the plastic solvent bottle.
5. Repeat this rinsing operation.
Administration of the vaccine:
Follow the User Manual instructions for the in-ovo injector equipment. The reconstituted vaccine should be used within 2 hours.
Subcutaneous administration of 0.1 ml per dose:
1. Calculate and prepare the required volume of the reconstituted vaccine as follows:
|
Cevac Transmune |
Solvent |
|
1 x 2,000 doses |
200 ml |
|
1 x 2,500 doses |
250 ml |
|
1 x 4,000 doses |
400 ml |
|
1 x 5,000 doses |
500 ml |
|
2 x 4,000 doses |
800 ml |
|
2 x 5,000 doses |
1,000 ml |
|
1 x 8,000 doses |
800 ml |
|
3 x 4,000 doses |
1200 ml |
|
4 x 4,000 doses |
1600 ml |
2. Draw up 2 ml of the solvent and transfer into the glass vial containing the lyophilised component.
3. Completely dissolve the vaccine by shaking gently and transfer it into the plastic solvent bottle.
4. Rinse the vial with another 2 ml liquid and transfer the rinsing liquid into the plastic solvent bottle.
5. Repeat this rinsing operation.
Administration of the vaccine:
Follow the User Manual instructions for the automatic syringe. The reconstituted vaccine should be used within 2 hours.
Adverse reactions
In vaccinated chickens, mild to moderate lymphocyte depletion is very commonly observed after the vaccine take, which is maximal at around 7 days after vaccine take. After 7 days, this depletion decreases and is followed by lymphocyte repopulation and regeneration of the bursa of Fabricius. In some cases, the replication of the vaccine strain may be prolonged (e.g. due to presence of very high maternal antibody titres in 1 day old chicks), and bursa scores can reach a maximum of 2.8 between 35 and 42 days of age, which does not affect the production parameters of the flock.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports)
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|---|---|
| Art. Nr. | 15052/4030 |
| EAN | 3411112269457 |
