Enzaprost
Active substance
ATC code
Species
Cattle: cows, heifers.
Pigs: sows, gilts.
Indications
The product is indicated for its luteolytic effects in cattle and pigs.
Cattle
The luteolytic effect of the product can be exerted in the following therapeutic uses:
1. Oestrus synchronisation.
2. Treatment of sub-oestrus or silent heat in cows which have a functional corpus luteum, but do not express behavioural oestrus.
3. Induction of abortion until day 120 of pregnancy.
4. Induction of parturition.
5. As an aid in the treatment of chronic metritis or pyometra where there is a functional or persistant corpus luteum.
Pigs
1. Induction of parturition from day 111 of pregnancy.
2. Post partum use: reduction of the weaning to oestrus interval (WOI) and the weaning to fertile service interval (WFSI) in sows with puerperal problems such as metritis in herds with reproductive problems.
Dose to be administered and administration route
Intramuscular use.
Full aseptic precautions should be taken. Use a sterile syringe and needle and make the injection through an area of clean skin. Care should be taken to avoid injection through wet or dirty areas of skin.
Cattle
1. Oestrus synchronisation:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per animal, to be repeated, if necessary after 11 (10 to 12) days.
Animals treated during dioestrus will normally return to oestrus and ovulate within two to four days after treatment.
Animals treated with the product may be bred by natural service, artificial insemination on detected oestrus or at fixed time insemination (72 and 96 hours after the second injection is usually recommended).
2. Treatment of sub-oestrus or silent heat in cows which have a functional corpus luteum, but do not express behavioural oestrus:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per animal, to be repeated, if necessary after 11 (10 to 12) days.
3. Induction of abortion until day 120 of pregnancy:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per animal.
The product may be used to terminate pregnancy in cattle until day 120 of pregnancy through its luteolytic effect.
4. Induction of parturition:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per animal on or after day 270 of gestation.
The interval from administration to parturition is one to eight days (average three days).
5. For the aid in the treatment of chronic metritis or pyometra where there is a functional or persistent corpus luteum:
One administration of 25 mg of dinoprost (as trometamol), ie 5 ml of the product per animal, to be repeated, if necessary after 11 (10 to 12) days.
Pigs
To avoid excessive broaching of the stopper when treating large numbers of animals using the 50 ml pack size, the use of a multiple dose syringe with a draw-off needle is recommended.
1. Induction of parturition from day 111 of pregnancy:
One administration of 10 mg of dinoprost (as trometamol), ie 2 ml of the product per animal within 3 days of expected parturition.
Response to treatment by individual animals varies within a range of 24-36 hours from administration to parturition. This can be used to control the time of farrowing in sows and gilts in late gestation. Treatment earlier than 3 days prior to predicted farrowing date may induce weak piglets.
2. Post-partum use:
One administration of 10 mg of dinoprost (as trometamol), ie 2 ml of the product per animal 24 to 36 hours after parturition.
Adverse reactions
Cattle
Increased rectal temperature (hyperthermia) has been reported very rarely.
However, rectal temperature changes have been transient in all cases observed and have not been detrimental to the animal. Limited salivation has been seen in some instances.
The side-effects disappear within one hour after the administration of PGF2α.
In cattle, if used for induction of parturition, retained foetal membranes may occur more frequently, depending on the time of use of the product.
Pigs
Transient side-effects consisting of increased body temperature, signs of pain at the site of injection increased respiratory rate, increased salivation, stimulation of defecation and urination, flushing of skin, dyspnea, slight ataxia, abdominal muscle spasms and vomiting occur occasionally following the administration of dinoprost in pregnant sows and gilts. These effects tend to parallel the signs exhibited by sows prior to normal parturition, only they appear to be condensed in time. These effects are usually seen within 10 minutes of injection and disappear within 3 hours. Nest building is a common behaviour 5 to 10 minutes after the administration of prostaglandin in sows that are housed in pen or pasture.
In very rare occasions , anaphylactic-type reactions, hyperactivity (restlessness – arching of back, pawing, and rubbing and gnawing the crate) and pruritus have been reported.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reactions)
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
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| Art. Nr. | 15052/5076 |
| EAN | 3411110041710 |
