Osphos
Active substance
ATC code
Species
Horses.
Indications
For the alleviation of clinical forelimb lameness associated with the bone resorptive processes of the distal sesamoid (navicular bone) in adult horses.
Dose to be administered and administration route
Intramuscular injection only. 1.53 mg clodronic acid per kg bodyweight, corresponding to 3 ml of the product per 100 kg body weight. Divide the total volume evenly for administration at 2 to 3 separate injection sites.
The maximum dose is 765 mg clodronic acid per horse (one 15 ml vial per horse >500 kg). Do not exceed the recommended dose.
Adverse reactions
In a clinical field study, administration of clodronic acid at 1.19 mg/kg to 142 horses resulted in the following frequency of adverse reactions: nervousness, lip licking, yawning and colic were common; head bobbing, transient swelling and/or pain at the injection site, pawing the ground, hives and pruritus were uncommon.
Episodes of renal insufficiency have been reported, rarely, during the postauthorisation period, and were more frequently observed in animals concurrently exposed to NSAIDs. In these cases, appropriate fluid therapy should be instituted and renal parameters monitored.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s)) - common (more than 1 but less than 10 animals in 100 animals displaying adverse reactions during the course of one treatment)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
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| Art. Nr. | 10434/4086 |
| EAN | 5701170422382 |
