Euthoxin vet.
Active substance
ATC code
Species
Dogs, cats, minks, polecats, hares, rabbits, guinea pigs, hamsters, rats, mice, chickens, pigeons, ornamental birds, small snakes, tortoises, lizards, frogs, horses, cattle, pigs.
Indications
Euthanasia.
Dose to be administered and administration route
Depending on species and circumstances this product may be administered via several routes.
The applicable dose depends on animal species and route of administration.
Therefore, the instructions described in the dosage scheme should be carefully followed:
Intravenous route
The intravenous route of administration should be the route of choice and adequate sedation should be administered if deemed necessary by the attending veterinarian.
For horses and cattle premedication is mandatory.
Intracardiac route
Where intravenous administration is difficult, and only following deep sedation or anaesthesia, the product may be administered via the intracardiac route in all target species except avian species.
Intraperitoneal route
Alternatively, for small animals only, administration via the intraperitoneal route could be used, but only following appropriate sedation.
Intrapulmonary route
Intrapulmonary administration must only be used as a last resort and only if the animal is heavily sedated, unconscious or anaesthetised and shows no response to noxious stimuli. This route of administration may only be used in chickens, pigeons, ornamental birds, snakes, tortoises, lizards and frogs.
Recommendations for dilution of product
Pigs (in case of administration in ear vein) and small animals (dogs, cats, mink, polecats, hares, rabbits, guinea pigs, hamsters, rats, mice, chickens, pigeons, ornamental birds): For ease of administration the product should be diluted with isotonic (0.9%) sodium chloride solution in a mixing ration of 1:1 prior to administration with needles thinner than 20G.
|
Target species |
Route |
Dose expressed as ml of the product |
Dose expressed as mg pentobarbital sodium |
|
Horses The product should be injected as quickly as possible. Premedication before administration is mandatory. |
Intravenous (rapid injection) |
1.0 ml per 5 kg |
100 mg per kg |
|
Cattle The product should be injected as quickly as possible. In cattle, in particular at lower dosages, it is possible to observe gasping in isolated cases. Premedication before administration is mandatory. |
Intravenous (rapid injection) |
1 - 2 ml per 10 kg |
50mg to 100 mg per kg |
|
Pigs The product should be injected as quickly as possible. The route of administration depends on the age and weight of the individual and can be intravenous (vena cava cranialis or ear vein) or intracardiac. The injection duration can - depending on the age and body weight of the pig –vary from 1 second (piglets) and 38 seconds (in boars> 100 kg body weight). |
Intravenous (vena cava cranialis) by rapid injection Intravenous (ear vein) by rapid injection after dilution with isotonic (0.9%) NaCl solution at a ratio of 1:1 Intracardiac (in unconscious or deeply sedated/anaesthetised patients) |
0.16 ml per kg up to 30 kg 0.08 ml per kg over 30 kg 0.16 ml per kg up to 30 kg 0.08 ml per kg over 30 kg 0.16 ml per kg up to 30 kg 0.08 ml per kg over 30 kg |
80 mg per kg up to 30kg 40 mg per kg over 30kg
80 mg per kg up to 30kg 40 mg per kg over 30kg
80 mg per kg up to 30kg 40 mg per kg over 30kg |
|
Dogs & Cats |
Intravenous; slow continuous injection until unconscious then rapid injection of remaining quantity Intracardiac &intraperitoneal: in unconscious or deeply sedated/anaesthetis ed patients |
1.0ml per 4 kg Dog 1.0 ml per 3 kg Cat
1.0 ml per 3 kg Dog 1.0 ml per 2 kg Cat |
125 mg per kg Dog 166 mg per kg Cat 166 mg per kg Dog 250 mg per kg Cat |
|
Mink, polecats |
Intravenous Intracardiac (in unconscious or deeply sedated/anaesthetis ed patients) |
1.0ml per animal |
500 mg per animal |
|
Hares, rabbits, guinea pigs, hamsters, rats, mice
|
Intravenous Intracardiac (in unconscious or deeply sedated/anaesthetis ed patients) Intraperitoneal (in unconscious or deeply sedated/anaesthetis ed patients) |
1.0ml per 1.5 kg 1.0 ml per 1kg |
333 mg per kg
500 mg per kg |
|
Chickens, pigeons, ornamental birds The method of choice in birds is intravenous injection. If venepuncture cannot be performed (due to e.g. haematoma, collapse of cardiovascular system) intrapulmonary injection could be an option. In birds, intrapulmonary injection is performed by inserting the cannula in a dorso-ventral direction on the left or right side of the backbone into the lung (3rd or 4th intercostal segment between backbone and scapula). |
Intravenous & Intrapulmonary (in unconscious or deeply sedated/anaesthetis ed patients) |
1.0 ml per 1 kg |
500 mg per kg |
|
Small snakes, tortoises, lizards, frogs |
Depending on the size, inject into the body cavity near the heart; death is expected after about 5 to 10 minutes in unconscious or deeply sedated/anaesthetis ed patients |
0.4 – 0.8 ml per animal |
200 to 400 mg per animal |
The stopper should not be punctured more than 50 times.
Adverse reactions
Minor muscle twitching may occur after injection. In cattle, gasping may occur if pentobarbital is administered below the recommended dose.
Use of the product may result in transient agitation and symptoms of shortness of breath.
Death may be delayed if the injection is administered perivascularly or into organs/tissues with low capacity for absorption.
Barbiturates can cause irritation when administered subcutaneously or perivascularly.
Administration by the intrapulmonary route causes coughing, gasping and respiratory distress.
Frequencies of adverse reactions:
Vocalisation, minor muscle twitching after injection are commonly observed.
One or few gasps after cardiac arrest are uncommonly reported.
Excitation, leg movements, defecation and urine loss, gasping (in cattle), mostly due to under-dosing were noted in rare cases
Convulsions, contraction of the diaphragm and vomiting are reported in very rare cases.
The frequency of adverse reactions is defined using the following convention:
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports)
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| Art. Nr. | 08749/4055 |
