Frontline Combo vet. (> 1 kg)

3 x 1 pc

Spot-on, solution

Active substance

Methoprene (S-Methoprene) : 60 mg/pipette

Fipronil : 50 mg/pipette

ATC code

QP53AX65 Fipronil, comb.

QP53AX Other ectoparasiticides for topical use

QP53A Ectoparaciticides for topical use, incl. insecticides

QP53 Ectoparaciticides, insecticides and repellents

QP Antiparasitic products, insecticides and repellents

Species

Cats and ferrets.

Indications

In cats:

To be used against infestations with fleas, alone or in association with ticks and/or biting lice.

- Elimination of fleas (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for six weeks after application.

- Elimination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus). The veterinary medicinal product has a persistent acaricidal efficacy for up to 2 weeks against ticks (based on experimental data).

- Elimination of biting lice (Felicola subrostratus).

The veterinary medicinal product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD).

In ferrets:

To be used against infestations with fleas, alone or in association with ticks.

- Elimination of ticks (Ixodes ricinus,). The veterinary medicinal product has a persistent acaricidal efficacy for 4 weeks against ticks (based on experimental data).

Dose to be administered and administration route

Spot-on use.

Underdosing could result in ineffective use and may favour resistance development.

Cats:

The minimum dose is 5 mg/kg bw of fipronil and 6 mg/kg bw of (S)-methoprene, corresponding to one pipette of 0.5 ml per cat.

In the absence of safety studies, the minimum treatment interval is 4 weeks.

Ferrets:

The dose is 50 mg of fipronil and 60 mg of (S)-methoprene per ferret, corresponding to one pipette of 0.5 ml per ferret.

The minimum treatment interval is 4 weeks.

For infestations with fleas and/or ticks, the need for and frequency of re-treatment(s) should be based on professional advice and should take into account the local epidemiological situation and the animal’s lifestyle.

Method of administration:

Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip. Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Adverse reactions

Cats and Ferrets:

Very rare

(< 1 animal / 10,000 animals treated, including isolated reports):

Application site reactions (skin scaling¹, hair loss¹, itching¹, reddening¹).

Generalised itching or hair loss.

Hypersalivation², vomiting.

Increased sensitivity to stimulation³, depression³, other nervous signs³.

¹ Transient

² If licking occurs, a brief period of hypersalivation may be observed due mainly to the nature of the carrier. ³ Reversible

Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.