Antisedan vet.
Active substance
ATC code
Species
Dogs and cats.
Indications
Atipamezole is indicated for the reversal of the sedative & analgesic effects of medetomidine or dexmedetomidine in dogs and cats. It also reverses all other effects of medetomidine or dexmedetomidine, such as cardiovascular and respiratory effects.
Dose to be administered and administration route
For intramuscular injection.
Dogs: The optimal dose of atipamezole in micrograms per kilogram is five times that of the previous medetomidine dose or 10 times the dexmedetomidine dose. Antisedan dose in millilitres is the same as that of medetomidine 1 mg/ml or dexmedetomidine 0.5 mg/ml dose. Antisedan dose in millilitres is one fifth (1/5) of the dose volume of dexmedetomidine 0.1 mg/ml. When medetomidine or dexmedetomidine have been used with or without butorphanol as a premedicant to thiopentone-halothane anaesthesia in dogs, or as premedicant to propofol anaesthesia in dogs, the product may be administered in the post-operative phase to reverse the effects of medetomidine or dexmedetomidine and hasten recovery.
Cats: The optimal dose of atipamezole in micrograms per kg is two-and-a-half times that of the previous medetomidine dose or five times the dexmedetomidine dose. The Antisedan dose in millilitres is half of that of medetomidine 1 mg/ml or dexmedetomidine 0.5 mg/ml dose and one tenth (1/10) of dexmedetomidine 0.1 mg/ml dose.
Example dosages:
Dogs:
|
Medetomidine dosage |
Dexmedetomidine 0.5 mg/ml dosage |
Dexmedetomidine 0.1 mg/ml dosage |
Antisedan dosage |
|
40 mcg/kg |
20 mcg/kg |
20 mcg /kg |
200 mcg/kg |
|
= 0.4 ml/10 kg |
= 0.4 ml/10 kg |
= 2.0 ml/10 kg |
= 0.4 ml/10 kg |
Cats:
|
Medetomidine dosage |
Dexmedetomidine 0.5 mg/ml dosage |
Dexmedetomidine 0.1 mg/ml dosage |
Antisedan dosage |
|
80 mcg/kg |
40 mcg/kg |
40 mcg/kg |
200 mcg/kg |
|
= 0.4 ml/5 kg |
= 0.4 ml/5 kg |
= 1.2 ml/3 kg* |
= 0.2 ml/5kg 0.12 ml/3kg |
* For cats weighing over 3 kg, dexmedetomidine 0.5 mg/ml is recommended. The dose in micrograms per kg should not exceed four times that of the previously administered medetomidine or eight times that of dexmedetomidine.
When cats have been anaesthetised with medetomidine or dexmedetomidine, with or without butorphanol, and ketamine the product may be administered to reverse the effects of medetomidine or dexmedetomidine and so speed recovery from anaesthesia. The veterinary medicinal product dosage in this instance is the same as that used for recovery after single administration of medetomidine or dexmedetomidine; however, the veterinary medicinal product should not be administered prior to 30 to 40 minutes following ketamine administration.
Adverse reactions
Adverse reactions are very rare.
In dogs a transient hypotensive effect has been observed during the first ten minutes post-injection. Vomiting, panting, defaecation and excessive salivation and muscle tremors (possibly shivering) have been reported but these effects appear to be very rare. Transient hyperactivity and tachycardia may be observed in a few individuals. In cats, when using low doses to partially reverse the effects of medetomidine or dexmedetomidine, the possibility of hypothermia (even when aroused from sedation) should be guarded against.
The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports)
| PRICE | Only for registered vets. Create a free profile to access all features.. Login |
|---|---|
| Art. Nr. | 06043/4004 |
| EAN | 5012674902110 |
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