Domitor vet.
Active substance
ATC code
Species
Dogs and Cats.
Indications
Dogs: For restraint, sedation and analgesia associated with clinical examinations and procedures, minor surgery and as premedication
prior to general anaesthesia
In combination with butorphanol for sedation and analgesia.
Cats: For restraint and sedation.
In combination with ketamine for the induction of general anaesthesia prior to surgical procedures
In combination with butorphanol for sedation and analgesia, and combined with both butorphanol and ketamine for general anaesthesia.
As a premedicant before alfaxalone/alfadolone for general anaesthesia.
Dose to be administered and administration route
An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes. Administration by intramuscular (IM), intravenous (IV) and subcutaneous (SC) routes are possible. The effect is most rapid after IV administration and slowest after SC administration. The dosage is dependent on the degree of sedation and analgesia required.
|
Domitor |
Dose mcg/kg |
|
Dogs |
10-80 |
|
Cats |
50-150 |
For sedation, small dogs require more Domitor per kg of bodyweight than large dogs thus the dosage per square meter of body surface could be more accurate. If this approach is used the dosage is 750 to 1000 mcg/square meter.
The following table gives the dosage for dogs on the basis of body weight.
|
Body weight (kg) IV administration |
Injection volume (ml) |
Body weight (kg) IM/ SC/ administration |
|
1.5-2.2 |
0.1 |
|
|
2.3-3.5 |
0.15 |
1.8-2.3 |
|
3.6-5.1 |
0.2 |
2.4-3.3 |
|
5.2-6.9 |
0.25 |
3.4-4.5 |
|
7.0-9.9 |
0.3 |
4.6-6.4 |
|
10.0-14.4 |
0.4 |
6.5-9.4 |
|
14.5-19.5 |
0.5 |
9.5-12.7 |
|
19.6-25.1 |
0.6 |
12.8-16.3 |
|
25.2-31.1 |
0.7 |
16.4-20.2 |
|
31.2-37.6 |
0.8 |
20.3-24.4 |
|
37.7-44.4 |
0.9 |
24.5-28.9 |
|
44.5-55.3 |
1.0 |
29.0-36.1 |
|
55.4-71.1 |
1.2 |
36.2-46.3 |
|
71.2-88.2 |
1.4 |
46.4-57.3 |
|
88.3 + |
1.6 |
57.4-75.8 |
|
2.0 |
75.9 + |
Anesthesia:
Domitor is suitable for use as an anesthetic premedication prior to general anesthesia. Premedication dosing guide: Medetomidine has marked anaesthetic-sparing effects. It is essential to reduce appropriately the dose of anaesthetic induction and maintenance agents in animals that have been given the product.
|
Combinant |
Dosage (Dogs) |
Dosage (Cats) |
|||
|
Domitor (mcg/kg) |
Combinant (mg/kg) |
Domitor (mcg/kg) |
Combinant (mg/kg) |
||
|
Propofol 10-40 |
1-4 |
NA |
NA |
||
|
Butorphanol 10-25 |
0.1 |
50 |
0.4 |
||
|
Ketamine |
80 |
2.5-7.5 |
|||
|
Butorphanol + NA Ketamine |
NA |
40-80 |
But: 0.1-0.4 Ket: 1.25-5.0 |
||
|
Alfaxalone NA /alfadolone |
NA |
80 |
2.5-5.0 |
||
Adverse reactions
Blood pressure will increase initially and then return to normal or slightly below normal. Bradycardia with occasional atrioventricular block may occur. Cyanosis has been reported.
Some dogs and most cats vomit 5 to 15 minutes after injection. Some cats may also vomit upon recovery.
Body temperature is slightly or moderately decreased and prolonged recovery may lead to hypothermia.
An increase in blood glucose concentration is seen due to alpha-2 adrenoreceptor mediated inhibition of insulin secretion.
Urination typically occurs during recovery at about 90 to 120 minutes posttreatment.
Some animals experience muscle tremors and may be sensitive to loud sounds.
Incidents of prolonged sedation and recurrence of sedation after initial recovery have been reported.
Isolated cases of hypersensitivity, paradoxical response (excitation) and lack of efficacy have been reported.
Death from circulatory failure with severe congestion of the lungs, liver, or kidney has been reported. Decreased respiratory rates with or without transient apnoea may occur. If the animal has a pre-existing subclinical respiratory disease, administration of Domitor can cause some significant respiratory depression which could predispose the animal to cardiac arrest. Pulmonary oedema has been reported.
The combination of Domitor and ketamine is reported to elicit a pain response in some cats when administered intramuscularly. Heart rates will generally decrease to approximately 50% of pre-anaesthetic levels and in some cats very slow respiratory rates are observed (4-6 breaths per minute).
In dogs, when Domitor is used in combination with propofol, movement of the forelegs may occur during induction of anaesthesia. In some cases at higher dosages, a decline in arterial oxygen tension may occur.
The frequency of adverse reactions is defined using the following convention: - very common (more than 1 in 10 animals displaying adverse reactions during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).
| PRICE | Only for registered vets. Create a free profile to access all features.. Login |
|---|---|
| Art. Nr. | 06043/4003 |
| EAN | 5012674902080 |
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