Domosedan Gel

1 x 3 ml
Oromucosal gel
SL

Species

Horse

Indications

Sedation to facilitate restraint for non-invasive veterinary procedures (e.g. passage of naso-gastric tube, radiography, rasping teeth) and minor husbandry procedures (e.g. clipping, shoeing).

Dose to be administered and administration route

The product is administered sublingually at 40 mcg/kg. The dosing syringe delivers the product in 0.25 ml increments. The following dosing table provides the dose volume to be administered for the corresponding body weight in 0.25 ml increments.

Approximate body weight (kg)

Dose volume (ml)

150 -

199

1.00

200 -

249

1.25

250 -

299

1.50

300 -

349

1.75

350 -

399

2.00

400 -

449

2.25

450 -

499

2.50

500 -

549

2.75

550 -

600

3.00

Instructions for dosing:

Apply impermeable gloves and remove the syringe from the outer carton. While holding the plunger, turn the ring-stop on the plunger until the ring is able to slide freely up and down the plunger. Position the ring in such a way that the side nearest the barrel is at the desired volume marking. Turn the ring to secure it in place.

Make sure that the horse’s mouth contains no feed. Remove the cap from the tip of the syringe and save for cap replacement. Insert the syringe tip into the horse’s mouth from the side of the mouth, placing the syringe tip beneath the tongue at the level of the corner of the mouth. Depress the plunger until the ring-stop contacts the barrel, depositing the product under the tongue.

Take the syringe out of the horse’s mouth, recap the syringe and return it to the outer carton for disposal. Remove and discard gloves or wash them in copious quantities of running water.

Should there be a substantial misdosing or swallowing of the product (e.g. the horse spits out or swallows more than an estimated 25% of administered dose), immediate replacement dosing of the lost portion should be attempted with care to avoid accidental overdosing. For animals in which the administered dose results in inadequate duration of sedation to complete the intended procedure, readministration of the product during the procedure may not be practical since transmucosal absorption is too slow to top-up the sedation. In such cases, a lip twitch may facilitate restraint. Alternatively, a veterinarian can administer additional injectable sedatives according to their clinical discretion.

Adverse reactions

All alpha-2 adrenoceptor agonists, including detomidine, may cause decreased heart rate, changes in the conductivity of cardiac muscle (as evidenced by partial atrioventricular and sinoauricular blocks), changes in the respiratory rate, incoordination/ataxia and sweating. A diuretic effect may be observed 2 to 4 hours after treatment. The potential for isolated cases of hypersensitivity exists, including paradoxical response (excitation). Because of continued lowering of the head during sedation, mucus discharges from the nose and, occasionally, oedema of the head and face may be seen. Partial, transient penis prolapse may occur in stallions and geldings. In rare cases, horses may show signs of mild colic following the administration of alpha-2 adrenoceptor agonists because substances of this class inhibit intestinal motility.

In studies with the product, the following adverse reactions have also been observed: transient erythema at the dose application site, piloerection, oedema of the tongue, hypersalivation, increased urination, flatulence, epiphora, allergic oedema, muscle tremors, and pale mucous membranes.

References

Leaflet is unavailable
Horse
PRICE Only for registered vets. Create a free profile to access all features.. Login
Art. Nr. 06043/4001
EAN 5012674902134
PACKAGES
Domosedan Gel
Vetoquinol
1 x 3 ml
06043/4001
VETiSearch ApS - C.F. Richs Vej 99D - 2000 Copenhagen - Denmark - contact@vetisearch.co.uk - Legal registration number: 39926679
VETiSearch.co.uk Copyright © 2025 . All rights reserved. This information is intended only for residents of Great Britain. The product information provided on this site is intended only for residents of Great Britain. Products may have different product information in different countries.