Alizin vet.
Active substance
ATC code
Species
Dogs (bitches).
Indications
Pregnant bitches: induction of abortion up to 45 days after mating.
Dose to be administered and administration route
Administer 10 mg per kg of bodyweight of aglepristone, equivalent to 0.33 ml of veterinary medicinal product per kg of bodyweight, twice, 24 hours apart.
|
Weight of bitch |
3 kg |
6 kg |
9 kg |
12 kg |
24 kg |
30 kg |
42 kg |
|
Volume of product |
1 ml |
2 ml |
3 ml |
4 ml |
8 ml |
10 ml |
14 ml |
Inject subcutaneously (only). Severe local reactions can be avoided if the veterinary medicinal product is administered into the scruff of the neck. A light massage of the injection site is recommended.
In large bitches, it is recommended that a maximum of 5 ml is injected at any one site.
This product does not contain an antimicrobial preservative. Swab the septum before removing each dose. Use a dry, sterile needle and syringe.
Following administration of the veterinary medicinal product to dogs, abortion (or resorption) occurs within 7 days.
Adverse reactions
In bitches treated after 20 days of gestation, abortion is accompanied by the physiological signs of parturition: fetal expulsion, vaginal discharge, reduced appetite, restlessness and mammary congestion. In field trials, 3.4 % of dogs suffered from uterine infections. After induced abortion with the veterinary medicinal product, an early return to oestrus is frequently observed (oestrus - oestrus interval shortened by 1 to 3 months).
Side effects such as anorexia (25 %), excitation (23 %), depression (21 %), vomiting (2 %) and diarrhoea (13 %) have been reported from field trials.
In field trials, the administration of the veterinary medicinal product produced pain during and shortly after injection in 17 % of dogs and a local inflammatory reaction at the injection site in 23 % of dogs. The size and intensity of this reaction depended on the volume of the veterinary medicinal product which was administered. Oedema, skin thickening, local lymph-node enlargement and ulceration may occur. All local reactions are reversible and will usually disappear within 28 days after injection.
In field trials, administration of the veterinary medicinal product induced haematological/biochemical changes in 4.5 % of dogs. These changes were always transient and reversible. The modified haematological parameters were as follows: neutrophilia, neutropaenia, thrombocytosis, haematocrit variation, lymphocytosis, lymphopaenia.
The modified (elevated) biochemical parameters were as follows: urea, creatinine, chloride, potassium, sodium, ALT, ALP, AST.
In rare cases (frequency > 1/10000 and < 1/1000), a hypersensitivity reaction has been/can be observed.
